Lymphoma

Question 1

What are lymphomas?

Answer 1

Cancers affecting lymphocytes, causing lymphadenopathy

Question 2

Age distribution of Hodgkin’s lymphoma?

Answer 2

Bimodal - 20 & 75.

Question 3

Presentation of lymphoma

Answer 3

Lymphadenopathy - axilla / inguinal / cervical. Non-tender rubbery mass (may be painful with alcohol)
Fever, weight loss, night sweats
Cough, itchiness, fatigue, SOB, abdominal pain, recurrent infections

Question 4

Ix in lymphoma

Answer 4

LN biopsy - Reed Sternberg cells
LDH can be raised - but not specific.
MRI / CT / PET

Question 5

What do Reed Sternberg cells look like?

Answer 5

Multiple nucleii, nucleoli

Question 6

Rx Hodgkin’s Lymphoma

Answer 6

Chemotherapy and radiotherapy

Question 7

Risks associated with treatment of Hodgkin’s lymphoma?

Answer 7

Chemo - leukaemia and infertility

Radiotherapy - cancer and damage to thyroid tissue

Question 8

Ann Arbor staging

Answer 8

1 - one region of LN
2 - 2 regions, same side of diaphragm (above or below
3 - LNs affected above and below the diaphragm
4 - non-lymphatic organs affected (lung, liver)

Question 9

Examples of non-hodgkin’s lymphoma

Answer 9

Burkitt’s
MALT
Diffuse large B cell lymphoma

Question 10

What is asssociated with Burkitt’s lymphoma

Answer 10

EBV HIV malaria

Question 11

What is associated with MALT?

Answer 11

H pylori infection

Question 12

How does diffuse large B cell lymphoma present?

Answer 12

Large rapidly growing painless mass in >65s.

Question 13

How do you differentiate between Hodgkin’s and non-Hodgkin’s lymphoma?

Answer 13

LN biopsy - present very similarly.

Question 14

Management of non-hodgkin’s lymphoma

Answer 14

Watchful waiting
Chemoo
Rituximab
Radiotherapy
SC transplant