Blood Film Results

Question 1

Anisocytosis description

Answer 1

Variation in size of RBC

Question 2

Target cells desription

Answer 2

Red centre, pale area, thick cytoplasm

Bullseye appearance

Question 3

Heinz bodies description

Answer 3

Blobs of denatured globin in RBC

Question 4

Howell-Jolly bodies description

Answer 4

Blobs of RNA in RBCs

Question 5

Reticulocytes description

Answer 5

Immature RBCs (larger, still contain RNA)
Usually ~1%, higher when there is a rapid turnover of RBCs

Question 6

Schistocytes description

Answer 6

Fragments of RBCs

Trauma in BV

Question 7

Sideroblasts description

Answer 7

Blobs of iron in RBCs

BM is unable to incorporate Fe into Hb molecules

Question 8

Smudge cells description

Answer 8

Ruptured WBCs

Fragile or old

Question 9

Spherocytes description

Answer 9

Spherical RBCs

Question 10

Anisocytosis associated disease

Answer 10

Myelodysplastic syndrome

Some anaemias

Question 11

Target cells associated disease

Answer 11

IDA

Post-splenectomy

Question 12

Heinz bodies associated disease

Answer 12

G6DP

A-thalassaemia

Question 13

Howell-Jolly Bodies associated disease

Answer 13

Post-splenectomy

Severe anaemia

Question 14

Reticulocytes associated disease

Answer 14

Haemolytic anaemia

Question 15

Schistocytes associated disease

Answer 15

Haemolytic uraemic syndrome
DIC
Thrombotic thrombocytopenic purpura
Metallic heart valves
Haemolytic anaemia

Question 16

Sideroblasts

Answer 16

Myelodysplastic syndrome

Question 17

Smudge cells associated disease

Answer 17

CLL

Question 18

Spherocytes associated disease

Answer 18

Autoimmune haemolytic anaemia

Hereditary spherocytosis