Lymphoid system and spleen

Question 1

where do B cells mature

Answer 1

bone marrow

Question 2

where do T cells mature

Answer 2

thymus

Question 3

what are primary lymphoid tissues

Answer 3

bone marrow and thymus

Question 4

what are peripheral symphoid tissues

Answer 4

lymph nodes
spleen
tonsils (waldeyer’s ring)
epithelia-lymphoid tissues bone marrow

Question 5

where do afferent channels of lymph node drain lymph to

Answer 5

through the collagenous capsule to peripheral sinus

Question 6

where do efferent channels drain lymph to

Answer 6

thoracic duct

left or left jugular, subclavian or bronchomediastinal trunks

Question 7

where does lymph enter venous system

Answer 7

left or right subclavian and jugular veins

Question 8

what cells are contained in lymph nodes

Answer 8

B cells 
T cells 
NK cells 
mononuclear phagocytes (pre-macrophage)
dendritic cells 
endothelial cells

Question 9

what does CD20 make

Answer 9

B cells

Question 10

what does CD3 make

Answer 10

T cells

Question 11

causes of local lymphadenopathy

Answer 11

infection
vaccination
trauma

Question 12

causes of systemic lymphadenopathy

Answer 12

infection

Autoimmune

Question 13

what lymphoid cell is predominantly stimulated in auto-immune conditions

Answer 13

B cell

Question 14

what lymphoid cell is predominantly stimulated in draining a tumour site

Answer 14

phagocytes

Question 15

what cell is predominantly stimulated in viral infections and in response to phenytoin

Answer 15

T cell

Question 16

which artery supplies the spleen

Answer 16

splenic artery

Question 17

what is the splenic artery a branch of

Answer 17

coeliac

Question 18

what vein drains the spleen

Answer 18

splenic vein

Question 19

what supports the sinusoids of the spleen

Answer 19

hoops of reticulin

Question 20

what cells do cords in red tissue contain

Answer 20

macrophages
some fibroblasts
some cells in transit

Question 21

role of the spleen

Answer 21

act as a filter for the blood

Question 22

clinical features of splenic enlargement

Answer 22

dragging sensation in LUQ
discomfort on breathing
pain if infarction
hyperslenism

Question 23

what is present in lymphatic vessels to ensure direction of flow

Answer 23

valves

Question 24

where do B cells lie in lymph node

Answer 24

follicles and germinal centre

Question 25

where do plasma cells lie in lymph nodes

Answer 25

medulla

Question 26

what happens in B cell response in a lymph node

Answer 26

enlarged follicles

Question 27

what can cause general lymphadenopathy

Answer 27

inflammatory process

widespread malignancy

Question 28

where does splenic vein drain to

Answer 28

superior mesenteric vein and splenic vein join to form portal vein

Question 29

what are the different tissue types of the spleen

Answer 29

red pulp
white pulp
surrounded by a capsule

Question 30

what does red pulp do

Answer 30

filter blood

Question 31

action of white pulp

Answer 31

main immunological area - facilitates immune responses to blood borne antigens

Question 32

what cells are contained in white pulp

Answer 32

T cells

Question 33

arterial supply of spleen

Answer 33

splenic artery - trabecular artery - central artery inside spleen - radial arterioles to perilymphoid sinuses - pencillar arteries - sheathed capillaries

Question 34

venous drainage of spleen

Answer 34

venous sinuses - trabecular vein - splenic vein

Question 35

what comprises periarteriolar lymphoid sheath

Answer 35

CD4+ T helper cells

Question 36

reasons for splenomegaly

Answer 36

infection (EBV, HIV, malaria, typhoid)
congestion 
haematological diseases (lymphoma, leukaemia, haemolytic anaemia, MPD)
autoimmune diseases 
storage diseases

Question 37

what is seen after splenectomy

Answer 37

Howell-jolly bodies

target cells