Haemopoeisis Flashcards
Name the granulocytes
neutrophils
eosinophils
basophils
function of eosinophils
hypersensitivity reactions
destroy parasites
name the lymphocytes
B cells
T cells
NK cells
life span of red cells
120 days
life span of neutrophils
7-8 hours
life span of platelets
7-10 days
what are megakaryocytes
pre-cursors of platelets
precursor of red cells
reticulocytes
what are myelocytes
nucleated precursor between neutrophils and neutroblasts
what blood cells all come from the CMP common precursor
MYELOID erythrocytes platelets granulocytes (neutrophils etc) macrophages dendritic cells
what blood cells come from the common CLP precursor
LYMPHOID T cells B cells NK cells dendritic cells
Where are the first haemopoietic stem cells acquired from
mesoderm
define stem cell differentiation
when then commit to one or more lineages
define stem cell maturation
when they acquire functional properties and stop proliferating
what is the first site of erythroid activity
yolk sac
when does bone marrow begin haemopoiesis
week 16
what is the main artery supplying an area of bone marrow called
nutrient artery
how are bone marrow sinuses different to capillaries
larger and discontinuous basement membrane
what is the myeloid:erythroid ratio?
relationship of neutrophils and precursors to proportion of nucleated red cell precursors
what do red blood cells break down to
iron
amino acid
bilirubin
where does erythroid maturation occur
around ‘nurse’ macrophages in the form of islands
what regulates neutrophil maturation
granulocyte-colony stimulating factor
what regulates growth and development of megakaryocytes from their precursors
thrombipoietin
what is the investigation used to antigen expression
immunophenotyping
