Haemopoeisis

Question 1

Name the granulocytes

Answer 1

neutrophils
eosinophils
basophils

Question 2

function of eosinophils

Answer 2

hypersensitivity reactions

destroy parasites

Question 3

name the lymphocytes

Answer 3

B cells
T cells
NK cells

Question 4

life span of red cells

Answer 4

120 days

Question 5

life span of neutrophils

Answer 5

7-8 hours

Question 6

life span of platelets

Answer 6

7-10 days

Question 7

what are megakaryocytes

Answer 7

pre-cursors of platelets

Question 8

precursor of red cells

Answer 8

reticulocytes

Question 9

what are myelocytes

Answer 9

nucleated precursor between neutrophils and neutroblasts

Question 10

what blood cells all come from the CMP common precursor

Answer 10

MYELOID 
erythrocytes
platelets
granulocytes (neutrophils etc) 
macrophages
dendritic cells

Question 11

what blood cells come from the common CLP precursor

Answer 11

LYMPHOID
T cells 
B cells 
NK cells 
dendritic cells

Question 12

Where are the first haemopoietic stem cells acquired from

Answer 12

mesoderm

Question 13

define stem cell differentiation

Answer 13

when then commit to one or more lineages

Question 14

define stem cell maturation

Answer 14

when they acquire functional properties and stop proliferating

Question 15

what is the first site of erythroid activity

Answer 15

yolk sac

Question 16

when does bone marrow begin haemopoiesis

Answer 16

week 16

Question 17

what is the main artery supplying an area of bone marrow called

Answer 17

nutrient artery

Question 18

how are bone marrow sinuses different to capillaries

Answer 18

larger and discontinuous basement membrane

Question 19

what is the myeloid:erythroid ratio?

Answer 19

relationship of neutrophils and precursors to proportion of nucleated red cell precursors

Question 20

what do red blood cells break down to

Answer 20

iron
amino acid
bilirubin

Question 21

where does erythroid maturation occur

Answer 21

around ‘nurse’ macrophages in the form of islands

Question 22

what regulates neutrophil maturation

Answer 22

granulocyte-colony stimulating factor

Question 23

what regulates growth and development of megakaryocytes from their precursors

Answer 23

thrombipoietin

Question 24

what is the investigation used to antigen expression

Answer 24

immunophenotyping