Lymphoid Structures I Flashcards
lymph node
encapsulated
filtration macros
store B and T cell
immune activation
follicle of lymph node
site of B cells
primary follicle
dense and dorminant
B cells
secondary follicle
pale germinal center
active B cell proliferation
medulla of lymph node
cords - packed lymphos and plasma cells
sinuses - communicate with efferent lymphatics
-contain reticular cells and macros
paracortex
holds T cells
has high endothelial venules - B and T cell enter from blood
not well developed in digeorge
high endothelial venules
cervical lymph nodes
head and neck
hilar lymph nodes
drain lungs
mediastinal lymph nodes
drain trachea and bronchi
axillary lymph nodes
drain upper limb, breast, skin above umbilicus
celiac lymph nodes
liver, stomach, spleen, pancreas, upper duodenum
superior mesenteric nodes
drain lower duodenum, jejunum, ileum, colon to splenic flexure
inferior mesenteric nodes
drain colon from splenic flexure to upper rectum
internal iliac nodes
drain lower rectum to anal canal - above pectinate line
bladder, vagina (middle third), and prostate
para-aortic nodes
drain testes, ovaries, kidneys, uterus
superficial inguinal nodes
drain anal canal - below pectinate line
skin below umbilicus, scrotum
popliteal nodes
drain dorsolateral foot and posterior calf
thoracic duct
drain 3/4 body
-to junction left subclavian and internal jugular vein
sinusoid of spleen
vascular channel in red pulp with fenestrated basement membrane
T cells in spleen
in periarteriolar lymphatic sheath - white pulp
B cells in spleen
in follicles of white pulp
marginal zone
of spleen
-between red and white pulp
APC and specialized B cells
APC capture blood-borne Ags for recognition
red pulp of spleen
location of RBCs
splenic dysfunction
low IgM
low complement activation
low C3b
susceptible to encapsulated organism
encapsulated organisms
strep pneumo h. flu type b n. meningitidis e. coli salmonella klebsiella group B strep
changes postsplenectomy
howel jolly bodies - nuclear remnants
thrombocytosis
lymphocytosis
thymus
site T cell differentiation and maturation
from 3rd pharyngeal pouch
thymus cortex
dense - immature T cells
thymus medulla
pale - mature T cells
hassal corpuscle
in thymus
epithelial reticular cells
T cell
thymus
B cells
bone marrow
