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Board Review - B - Immunology > Immune Responses II > Flashcards

Immune Responses II Flashcards

1
Q

passive immunity

A

receive preformed antibodies

rapid onset
but short duration of action - 3 weeks

ex- IgA in breast milk or maternal IgG cross placenta

and tx for some infections - tetanus toxin Ab, botulinum toxin Ab, HBV, varicella, rabies, etc.

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2
Q

active immunity

A

exposure to foreign antigen
slow response
but long lasting protection

with vaccines and natural infection

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3
Q

live attenuated vaccine

A

induce cell and humoral response
-lifelong immunity

MMR - only live attenuated given to HIV positive patient

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4
Q

live attenuated vaccines

A 
MMR
polio - sabin
influenza - intranasal
yellow fever
varicella zoster
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5
Q

killed vaccines

A

rabies
influenza - injection
polio - salk
-hep A

induce humoral response

need boosters

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6
Q

type I HS

A

Ag cross link IgE

immediate release vasoactive amines - postcap venules - histamine

delayed response - leukotriene AA metabolites

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7
Q

not Ab mediated

A

type IV HS

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8
Q

type II HS

A

cytotoxic - antibody mediated

IgM or IgG bind antigen on enemy cell
-cellular destruction occurs

opsonization
complement inflammation
antibody mediated cell destruction

MAC formation

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9
Q

direct and indirect coombs

A

type II HS

direct - Abs that have adhered to patients RBCs

indirect - serum Abs that can adhere to other RBCs

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10
Q

type III HS

A

immune complex mediated

Ag-Ab complex

serum sickness and arthus rxn

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11
Q

serum sickness

A

IC disease - Abs to foreign proteins produces

IC form and deposit in membranes - fix complement

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12
Q

arthus rxn

A

subacute Ab mediated HS rxn

intradermal injection of Ag - induce Abs

Ag-Ab complex in skin - edema, necrosis, complement activation

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13
Q

type IV HS

A

delayed - T cell mediated

sensitized T cells - encounter antigen and release cytokines

NO ANTIBODY INVOLVEMENT

TB skin test, transplant rejection, contact dermatitis, PPD test

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14
Q

swelling and inflammation after tetanus vaccine

A

arthur rxn - type III HS

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15
Q

graft vs host disease

A

type IV HS

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16
Q

multiple sclerosis

A

type IV HS

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17
Q

contact dermatitis

A

type IV HS

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18
Q

IgA deficient individual

A

need transfusion without IgA

19
Q

ABO blood group incompatability

A

type II HS rxn

20
Q

anti ACh Ab

A

myasthenia gravis

21
Q

anti BM Ab

A

goodpasture

22
Q

anticardiolipid Ab

A

SLE, antiphospholipid Ab syndrome

23
Q

anticentromere Ab

A

CREST

24
Q

anti-desmoglein Ab

A

desmosome

pemphigoid vulgaris

25
Q

anti dsDNA and anti-smith Abs

A

SLE

26
Q

anti-glutamic acid decarboxylase Abs

A

DM I

anti GAD-65 Abs

27
Q

anti-hemidesmosome Abs

A

bullous pemphigoid

28
Q

anti-histone Abs

A

drug induced lupus

29
Q

anti-Jo1, anti-SRP, anti-Mi2 Abs

A

polymyositis

dermatomyositis

30
Q

antimicrosomal Ab

A

hashimotos

31
Q

antithyroglobulin Ab

A

hashimotos

32
Q

antimitochondrial Ab

A

primary biliary cirrhosis

33
Q

antiparietal cell Ab

A

pernicious anemia

34
Q

anti-Scl-70 Abs

A

scleroderma - diffuse

anti -DNA topoisomerae I

35
Q

anti smooth m Ab

A

autoimmune hepatitis

36
Q

anti-SSA and anti SSB Ab

A

anti-Ro and anti-La

sjogrens

37
Q

anti TSH receptor Ab

A

graves disease

38
Q

anti-U1 RNP Ab

A

mixed CT disease

39
Q

anti endomysial Abs

A

celiac disease

IgA

40
Q

anti transglutaminase Abs

A

celiac disease

IgA

41
Q

p-ANCA

A

MPO Abs

microscopic polyangiitis
eosinophilic granulomatosis with polyangiitis - churg strauss

42
Q

c-ANCA

A

PR3 Abs

granulomatosis with polyangiitis - wegener

43
Q

anti-CCP Abs

A

specific - rheumatoid arthritis

44
Q

rheumatoid factor

A

IgM Ab that targets IgG Fc region

not as specific as anti-CCP

Board Review - B - Immunology (6 decks)

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