Lymphocytes I

Question 1

pathogen recognition innate immunity

Answer 1

TLRs - recognize PAMPs

examples/
LPS - gram negative
flagellin - bacteria
ssRNA - viruses

Question 2

MHC I gene

Answer 2

HLA A, B, C

Question 3

MHC II gene

Answer 3

HLA DR, DP, DQ

Question 4

expressed all nucleated cells

Answer 4

MHC class I

NOT on RBCs

Question 5

present endogenous antigens

Answer 5

MHC class I

to CD8 T cells

Question 6

present exogenous antigens

Answer 6

MHC class II

to CD4 T cells

Question 7

protein with MHC class I

Answer 7

beta-2 microglobulin

Question 8

protein with MHC class II

Answer 8

invariant chain

Question 9

MHC I antigen loading

Answer 9

Ag peptide loaded onto MHC I in RER after delivery

delivery via TAP - transporter associated with antigen processing

Question 10

MHC II antigen loading

Answer 10

Ag loaded following release of invariant chain

-in acidified endosome

Question 11

hemochromatosis HLA

Answer 11

HLA A3

Question 12

psoriatic arthritis HLA

Answer 12

HLA B27

Question 13

ankylosing spondylitis HLA

Answer 13

HLA B27

Question 14

arthritis of IBD HLA

Answer 14

HLA B27

Question 15

reactive arthritis HLA

Answer 15

HLA B27

Question 16

celiac disease HLA

Answer 16

HLA DQ2/DQ8

Question 17

multiple sclerosis HLA

Answer 17

HLA DR2

Question 18

SLE HLA

Answer 18

HLA DR2

Question 19

graves disease HLA

Answer 19

HLA DR2

Question 20

hashimotos thyroiditis HLA

Answer 20

HLA DR2

Question 21

rheumatoid arthritis HLA

Answer 21

HLA DR4

Question 22

diabetes I HLA

Answer 22

HLA DR4

Question 23

pernicious anemia HLA

Answer 23

HLA DR5

Question 24

natural killer cell action

Answer 24

perforin and granzyme

-induce apoptosis of cells

Question 25

trigger for NK cells

Answer 25

lack of MHC class I

and CD16 - bind Fc region of bound Ig

Question 26

CD16

Answer 26

on NK cell

bind Fc region of bound Ig

Question 27

B cell function

Answer 27

recognize Ag
produce Ab
maintain immunologic memory - memory B cells

Question 28

T cell function

Answer 28

CD4 - help B cell male Abs
-and produce cytokine - activate other leukocytes

CD8 - kill virus infected cells

Question 29

type IV hypersens

Answer 29

mediated by T cells

Question 30

T cell differentiation

Answer 30

positive selection - thymic cortex

negative selection - thymic medulla

Question 31

IL-12

Answer 31

stimulus for Th1 response

Question 32

IL-4

Answer 32

stimulus for Th2 response

Question 33

TGF-B and IL-6

Answer 33

stimuli for Th17 response

Question 34

Th1 cells

Answer 34

secrete IFN-gamma
-activate macros and CD8 T cells

inhibited by IL-4 and IL-10 from Th2

Question 35

Th2 cells

Answer 35

secrete IL-4, IL-5, IL-10, IL-13

recruit eosinos parasite defense
and promote IgE production by B cells

inhibited by IFN-gamma - from Th1 cell

Question 36

macro-lympho interaction

Answer 36

macro - release IL-12 - stimulate T cell to Th1

Th1 cell - release IFN-gamma - stimulate macro

Question 37

CD8 T cells

Answer 37

MHC class I on virus infected cells

release perforin and granzyme B

Question 38

regulatory T cells

Answer 38

suppress CD4 and CD8 T cell fxns

CD3, CD4, CD25, FOXP3 positive

produce anti-inflammatory cytokines
-IL-10 and TGF-B