Lymphocytes I Flashcards
pathogen recognition innate immunity
TLRs - recognize PAMPs
examples/
LPS - gram negative
flagellin - bacteria
ssRNA - viruses
MHC I gene
HLA A, B, C
MHC II gene
HLA DR, DP, DQ
expressed all nucleated cells
MHC class I
NOT on RBCs
present endogenous antigens
MHC class I
to CD8 T cells
present exogenous antigens
MHC class II
to CD4 T cells
protein with MHC class I
beta-2 microglobulin
protein with MHC class II
invariant chain
MHC I antigen loading
Ag peptide loaded onto MHC I in RER after delivery
delivery via TAP - transporter associated with antigen processing
MHC II antigen loading
Ag loaded following release of invariant chain
-in acidified endosome
hemochromatosis HLA
HLA A3
psoriatic arthritis HLA
HLA B27
ankylosing spondylitis HLA
HLA B27
arthritis of IBD HLA
HLA B27
reactive arthritis HLA
HLA B27
celiac disease HLA
HLA DQ2/DQ8
multiple sclerosis HLA
HLA DR2
SLE HLA
HLA DR2
graves disease HLA
HLA DR2
hashimotos thyroiditis HLA
HLA DR2
rheumatoid arthritis HLA
HLA DR4
diabetes I HLA
HLA DR4
pernicious anemia HLA
HLA DR5
natural killer cell action
perforin and granzyme
-induce apoptosis of cells