Lymphocytes I Flashcards

1
Q

pathogen recognition innate immunity

A

TLRs - recognize PAMPs

examples/
LPS - gram negative
flagellin - bacteria
ssRNA - viruses

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2
Q

MHC I gene

A

HLA A, B, C

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3
Q

MHC II gene

A

HLA DR, DP, DQ

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4
Q

expressed all nucleated cells

A

MHC class I

NOT on RBCs

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5
Q

present endogenous antigens

A

MHC class I

to CD8 T cells

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6
Q

present exogenous antigens

A

MHC class II

to CD4 T cells

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7
Q

protein with MHC class I

A

beta-2 microglobulin

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8
Q

protein with MHC class II

A

invariant chain

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9
Q

MHC I antigen loading

A

Ag peptide loaded onto MHC I in RER after delivery

delivery via TAP - transporter associated with antigen processing

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10
Q

MHC II antigen loading

A

Ag loaded following release of invariant chain

-in acidified endosome

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11
Q

hemochromatosis HLA

A

HLA A3

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12
Q

psoriatic arthritis HLA

A

HLA B27

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13
Q

ankylosing spondylitis HLA

A

HLA B27

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14
Q

arthritis of IBD HLA

A

HLA B27

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15
Q

reactive arthritis HLA

A

HLA B27

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16
Q

celiac disease HLA

A

HLA DQ2/DQ8

17
Q

multiple sclerosis HLA

18
Q

SLE HLA

19
Q

graves disease HLA

20
Q

hashimotos thyroiditis HLA

21
Q

rheumatoid arthritis HLA

22
Q

diabetes I HLA

23
Q

pernicious anemia HLA

24
Q

natural killer cell action

A

perforin and granzyme

-induce apoptosis of cells

25
trigger for NK cells
lack of MHC class I and CD16 - bind Fc region of bound Ig
26
CD16
on NK cell bind Fc region of bound Ig
27
B cell function
recognize Ag produce Ab maintain immunologic memory - memory B cells
28
T cell function
CD4 - help B cell male Abs -and produce cytokine - activate other leukocytes CD8 - kill virus infected cells
29
type IV hypersens
mediated by T cells
30
T cell differentiation
positive selection - thymic cortex | negative selection - thymic medulla
31
IL-12
stimulus for Th1 response
32
IL-4
stimulus for Th2 response
33
TGF-B and IL-6
stimuli for Th17 response
34
Th1 cells
secrete IFN-gamma -activate macros and CD8 T cells inhibited by IL-4 and IL-10 from Th2
35
Th2 cells
secrete IL-4, IL-5, IL-10, IL-13 recruit eosinos parasite defense and promote IgE production by B cells inhibited by IFN-gamma - from Th1 cell
36
macro-lympho interaction
macro - release IL-12 - stimulate T cell to Th1 Th1 cell - release IFN-gamma - stimulate macro
37
CD8 T cells
MHC class I on virus infected cells release perforin and granzyme B
38
regulatory T cells
suppress CD4 and CD8 T cell fxns CD3, CD4, CD25, FOXP3 positive produce anti-inflammatory cytokines -IL-10 and TGF-B