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Board Review - B - Immunology > Lymphocytes I > Flashcards

Lymphocytes I Flashcards

1
Q

pathogen recognition innate immunity

A

TLRs - recognize PAMPs

examples/
LPS - gram negative
flagellin - bacteria
ssRNA - viruses

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2
Q

MHC I gene

A

HLA A, B, C

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3
Q

MHC II gene

A

HLA DR, DP, DQ

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4
Q

expressed all nucleated cells

A

MHC class I

NOT on RBCs

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5
Q

present endogenous antigens

A

MHC class I

to CD8 T cells

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6
Q

present exogenous antigens

A

MHC class II

to CD4 T cells

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7
Q

protein with MHC class I

A

beta-2 microglobulin

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8
Q

protein with MHC class II

A

invariant chain

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9
Q

MHC I antigen loading

A

Ag peptide loaded onto MHC I in RER after delivery

delivery via TAP - transporter associated with antigen processing

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10
Q

MHC II antigen loading

A

Ag loaded following release of invariant chain

-in acidified endosome

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11
Q

hemochromatosis HLA

A

HLA A3

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12
Q

psoriatic arthritis HLA

A

HLA B27

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13
Q

ankylosing spondylitis HLA

A

HLA B27

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14
Q

arthritis of IBD HLA

A

HLA B27

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15
Q

reactive arthritis HLA

A

HLA B27

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16
Q

celiac disease HLA

A

HLA DQ2/DQ8

17
Q

multiple sclerosis HLA

A

HLA DR2

18
Q

SLE HLA

A

HLA DR2

19
Q

graves disease HLA

A

HLA DR2

20
Q

hashimotos thyroiditis HLA

A

HLA DR2

21
Q

rheumatoid arthritis HLA

A

HLA DR4

22
Q

diabetes I HLA

A

HLA DR4

23
Q

pernicious anemia HLA

A

HLA DR5

24
Q

natural killer cell action

A

perforin and granzyme

-induce apoptosis of cells

25
Q

trigger for NK cells

A

lack of MHC class I

and CD16 - bind Fc region of bound Ig

26
Q

CD16

A

on NK cell

bind Fc region of bound Ig

27
Q

B cell function

A

recognize Ag
produce Ab
maintain immunologic memory - memory B cells

28
Q

T cell function

A

CD4 - help B cell male Abs
-and produce cytokine - activate other leukocytes

CD8 - kill virus infected cells

29
Q

type IV hypersens

A

mediated by T cells

30
Q

T cell differentiation

A

positive selection - thymic cortex

negative selection - thymic medulla

31
Q

IL-12

A

stimulus for Th1 response

32
Q

IL-4

A

stimulus for Th2 response

33
Q

TGF-B and IL-6

A

stimuli for Th17 response

34
Q

Th1 cells

A

secrete IFN-gamma
-activate macros and CD8 T cells

inhibited by IL-4 and IL-10 from Th2

35
Q

Th2 cells

A

secrete IL-4, IL-5, IL-10, IL-13

recruit eosinos parasite defense
and promote IgE production by B cells

inhibited by IFN-gamma - from Th1 cell

36
Q

macro-lympho interaction

A

macro - release IL-12 - stimulate T cell to Th1

Th1 cell - release IFN-gamma - stimulate macro

37
Q

CD8 T cells

A

MHC class I on virus infected cells

release perforin and granzyme B

38
Q

regulatory T cells

A

suppress CD4 and CD8 T cell fxns

CD3, CD4, CD25, FOXP3 positive

produce anti-inflammatory cytokines
-IL-10 and TGF-B

Board Review - B - Immunology (6 decks)

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