Immune Responses I Flashcards
IL-1
from macros
fever
acute inflammation
activate endothelium adhesion molecules
IL-6
from macros
fever
stimulate acute phase reactant production
IL-8
from macros
chemotactic factor for neutrophils
IL-12
from macros
induce T cells - to Th1 cells
activate NK cells
TNF-a
from macros
mediate septic shock
activate endothelium
WBC recruitment
vascular leak
cachexia
TNF -a
IL-2
from all T cells
stimulate growth of helper, cytotoxic, reg T cells
stimulate grwoth NK cells
IL-3
from all T cells
stimulate growth and differentiation of bone marrow stem cells
IFN-gamma
from Th1 cells
stimulate macrophage
and activate NK cell
IL-4
from Th2 cell
induce differentiation into Th2 cells
promote B cell growth
enhanced class switching - IgE and IgG
IL-5
from Th2 cells
promote differentiation of B cells
class switch to IgA cells
growth and differentiation of eosinophils
IL-10
from Th2 cells
modulate inflammation
decreased MHC class II and Th1 cytokines
inhibit macros and dendritic cells
inhibitors of immune response
IL-10
TGF-B
NADPH oxidase deficiency
chronic granulomatous disease
no O2 to superoxide - O2-
superoxide dismutase
O2- to H2O2
