Immune Responses I Flashcards

1
Q

IL-1

A

from macros

fever
acute inflammation
activate endothelium adhesion molecules

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2
Q

IL-6

A

from macros

fever
stimulate acute phase reactant production

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3
Q

IL-8

A

from macros

chemotactic factor for neutrophils

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4
Q

IL-12

A

from macros

induce T cells - to Th1 cells

activate NK cells

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5
Q

TNF-a

A

from macros

mediate septic shock
activate endothelium
WBC recruitment
vascular leak

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6
Q

cachexia

A

TNF -a

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7
Q

IL-2

A

from all T cells

stimulate growth of helper, cytotoxic, reg T cells
stimulate grwoth NK cells

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8
Q

IL-3

A

from all T cells

stimulate growth and differentiation of bone marrow stem cells

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9
Q

IFN-gamma

A

from Th1 cells

stimulate macrophage

and activate NK cell

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10
Q

IL-4

A

from Th2 cell

induce differentiation into Th2 cells

promote B cell growth

enhanced class switching - IgE and IgG

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11
Q

IL-5

A

from Th2 cells

promote differentiation of B cells

class switch to IgA cells

growth and differentiation of eosinophils

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12
Q

IL-10

A

from Th2 cells

modulate inflammation

decreased MHC class II and Th1 cytokines

inhibit macros and dendritic cells

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13
Q

inhibitors of immune response

A

IL-10

TGF-B

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14
Q

NADPH oxidase deficiency

A

chronic granulomatous disease

no O2 to superoxide - O2-

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15
Q

superoxide dismutase

A

O2- to H2O2

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16
Q

myeloperoxidase

A

H2O2 and Cl to HClO

17
Q

bacterial catalase

A

H2O2 to H2O and O2

18
Q

glutathione reductase

A

require selenium

19
Q

selenium

A

for both glutathione reductase and peroxidase

20
Q

bleach

A

HClO
hypochlorite

formed by myeloperoxidase

21
Q

respiratory burst

A

activation of phagocte NADPH oxidase

-use O2 to form superoxide

22
Q

color of sputum

A

blue green

from myeloperoxidase

23
Q

phagocyte of patient with chronic granulomatous disease

A

use H2O2 from organism to generate ROS

increased risk infection of catalase positive species
-bc these can get rid of H2O2

staph aureus, aspergillus

24
Q

pyocyanin of pseudomonas

A

generate ROS to kill competing microbes

25
interferon a and B
defense RNA and DNA viruses glycoproteins -act locally on uninfected cells prime them for viral defense -help selectively degrade viral nucleic acid and protein result in apoptosis - disrupt viral amplification
26
MHC class I
on all nucleated cells not RBCs
27
T reg cells
CD4 | CD25
28
CD28
on T cells binds B7 - on B cells and APCs
29
CD16
NK cells
30
CD56
NK cell
31
CD34
hematopoietic stem cells
32
CD14 and CD40
macros
33
anergy
stage where cell cannot be activated by exposure to its antigen if T or B cell activated without costimulatory signal mechanism of self tolerance
34
superantigens
cross link beta region fo T cell receptor to MHC class II activate any CD4 T cell massive release of cytokines
35
RNA segment assortment
influenza virus segmented RNA virus
36
salmonella variation
2 flagellar variants
37
n. gonorrhea antigen variation
pilus protein