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Immunology > Lymphoid Organs and Cell Migration > Flashcards

Lymphoid Organs and Cell Migration Flashcards

1
Q

what cells are in involved in innate immunity

A

phagocytes and APCs

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2
Q

what cells are involved in adaptive immunity

A

B cell and T cells

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3
Q

what are the primary lymphoid organs

A

bone marrow and thymus

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4
Q

where do all immune cells except t cells develop

A

bone marrow

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5
Q

where do t cells develop

A

thymus

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6
Q

what are the secondary lymphoid organs

A

lymph nodes
spleen
GALT

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7
Q

what influences stem cell differentiation

A

cell to cell contact

presence of cytokines

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8
Q

what are HSCs?

A

totipotent haemopoietic stem cell

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9
Q

what produces cytokines

A

T helper cells and APCs

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10
Q

what are cytokines?

A

intercellular communication molecules

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11
Q

what are pleiotropic cytokines?

A

cytokines with many functions

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12
Q

what are redundant cytokines?

A

cytokines with similar functions

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13
Q

what is the target cell of Th1

A

macrophages

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14
Q

what cytokines are released by Th1

A

IL2, IFNy, TNFa

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15
Q

what is the target cell of Tfh?

A

B cells - autoimmunity

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16
Q

how do B cells produce functional B cell surface receptors?

A

recombine heavy and light chain genes

17
Q

what are the two regions of the thymus

A 
outer cortex (immature)
inner medulla (mature)
18
Q

what is the spleen composed of?

A

white pulp- T and B cells

red pulp - removal of RBCs and platelets

19
Q

what is the function of the lymph nodes

A

filter antigens from interstitial fluid and lymph

20
Q

what is MALT

A

mucosal lymphoid tissue

21
Q

what are the 3 component of the inflammatory response

A
  1. increased blood supply
  2. increased capillary permeability
  3. leucocyte migration
22
Q

what cells appear first in inflammation

A

neutrophils
APCs
CTLs
B lymphocytes

23
Q

what is chemotaxis

A

directional migration of cells up a concentration gradient of chemotactic molecules

24
Q

what is chemokinesis

A

no directional movement of cells

25
Q

what are the chemotactic molecules

A

c5a - complement protein
chemokines
bacterial peptide -f-met-leu-phe

Immunology (10 decks)

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