Hypersensitivity and Allergy Flashcards
1
Q
outline type I hypersensitivity
A
mast cells bind IgE via FceRI Fc receptor IgE cross linking mast cell degranulation release of mediators
2
Q
how is eczema treated
A
corticosteroids cyclosporin
3
Q
what are the properties of allergens
A
mainly proteins
glycosylated
small amounts sufficient
small MW - promote GIT survival
4
Q
what is IgE bound by
A
Fc receptors on mast cells and basophils
5
Q
what does a B2 agonist do
A
beta blockers block binding of adrenaline and noradrenaline causing airways to relax
6
Q
what are the new treatments to hypersensitivity
A
- desensitisation
- monoclonal anti IgE
- recombinant IL4 receptor
7
Q
what plays a major role in IgE and Histamine-induced
vascular endothelium dysfunction
A
IL4
8
Q
what are the immune inductive sites in the GIT
A
peyers patches
mesenteric lymph nodes
lamina propria
