Cells of the Immune System Flashcards
what type receptors are involved in the innate system
primitive and broad
TLRS
what type of receptors are involved in the adaptive system
highly specific
TCRs and BCRs
differences between adaptive and innate immunty
adaptive:
- slow
- highly regulated
- amplified
- long duration
- long memory
what are the primary lymphoid organs
bone marrow and thymus
what are the secondary lymphoid organs
lymph nodes
spleen
what are the sites of haemopoiesis
primary lymphoid organs
bone marrow and thymus
how does the skin protect against infection
keratinized cells shedding dryness acidity antagonistic pathogens
how does the respiratory tract defend against infection
cilia
coughing and sneezing
colonised by staph and strep
washed by salivation into acidic stomach
what are neutrophil extracellular traps
networks of secreted extracellular fibres composed of DNA and granule contents
what do neutrophil extracellular traps release
antimicrobial proteins such as neutrophil elastase, cathepsin g and histones
what do neutrophil extracellular traps do
kill bacteria and act as physical barrier that prevents the spread of the pathogen
what do cell surface TLRs recognise
lipoproteins and peptidoglycan
what do NLR and RLRs detect?
bacteria and viruses in the cytoplasm
what do TLR4 recognise
LPS on gram neg bacteria
what do TLR5 recognise
flagellin on motile bacteria
