lymphoid organ histology Flashcards

1
Q

where do B cells maturation occure

A

Bone Marrow
Bursa of Fabricus in Birds
Peyers Patches in Ruminants

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2
Q

where are T cells matured

A

Thymus in Mammals

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3
Q

what cells differentiate into plasma cells (and therefore then antibodies)

A

B cells

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4
Q

what is the function of primary lymphoid tissue

A

generate specific immune cells

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5
Q

what is the function of secondary lymphoid tissue

A

generate immune responses (recognise foreign antigens)

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6
Q

which lymph organs have a cortex and a medulla

A

thymus
Bursa of Fabricius
Lymph nodes

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7
Q

what happens to the thymus with sexual maturity

A

it involutes and is replaced with fat

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8
Q

why is it important that pathogens don’t enter the thymus

A

WBC will be exposed to them and not recognise them as a foreign antigen

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9
Q

how can you identify a histology of the thymus

A

bright pink Hassals Corpuscles in the medulla

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10
Q

what is found between the cortex and medulla of the bursa of fabricius

A

pseudostrratisfied of columnar epithelium and undifferentiated epithelial (capillary cells)

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11
Q

how may the bursa of Fabricius also act as a secondary lymphoid organ

A

have columnar epithelium also which allow it to take in and present antigens

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12
Q

in which animals are Peyers patches considered a primary lymphoid organ

A

ruminants

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13
Q

What is found at the edge of the lymph node

A

subcapsula sinus
(beneath the Connective tissue capsule)

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14
Q

what is a germinal centre

A

region in the cortex where B cells mature

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15
Q

in which animals are lymph nodes considered inside out and how is it different

A

pig
afferent lymphoid at the base
germinal centres in the centre

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16
Q

what is found in the spleen capsule and what is its purpose

A

smooth muscle
for contraction so erythrocytes are released

17
Q

what is the function of red pulp in the spleen

A

contain blood vessels - secrete more erythrocytes when needed
breakdown erythrocytes, retrieve iron
filter blood to remove pathogens or dead erythrocytes

18
Q

what is the function of the white pulp

A

contains lymphoid tissue

19
Q

which cells retrieve iron in the red pulp

A

haemosiderophages

20
Q

where are T cells found in the spleen

A

Periarteriolar lymphoid sheath (in the white pulp)

21
Q

what cell type lines the tonsils

A

stratified squamous epithelium

22
Q

what is the function of the intraepithelial lymphocytes

A

recognise foreign antibodies

23
Q

what lies on the outside of the tonsils

A

thin connective tissue

24
Q

what are trabeculae

A

thin fibres of smooth muscle