Haemostasis Flashcards
Define Haemostasis
Process where blood coagulation starts and ends
And the clot is removed in a regulated manor
Briefly outline the steps of haemostasis
Vasoconstriction restricts blood flow to the wound
Platelets are formed
Soluble Fibrinogen is converted to insoluble fibrin by thrombin
Eventually fibrous is removed the clot
Why is haemostasis important
Injury response
Prevent microbe entry
Stops incorrect clots from being formed
Prevents thrombosis
What do platelets sense
Proteins at the site of vascular injury
What causes thrombin generation
Activated platelets at the injury site
Where are platelets formed
Bone marrow
What regulated platelet production
Thrombopoietin
What are platelet activation key binding partners
Collagen
Von Willebrand factor
What occurs when key binding partners bind to platelet adhesion molecules
Granules released that contain ADP and Thromboxane
And other clotting factors like VWF fibrinogen P selection
What is the importance of ADP release in platelet activation
Stimulated further platelet activation
Where are binding partners found
Subendothelial matrix
What promotes thrombin generation
Negatively charges phospholipid surface
What is primary homeostasis
Activation of platelets at the site of injury
What are the proteases in the coagulation process
Serine proteases
How do serine proteases get activated
Pro-cofactors
What is the initial blood clotting trigger factor
Tissue factor
Where is tissue factor found
On the cell surface of cells that don’t interact with blood
What is haemophilia
An inherited disorder where the blood does not clot properly
Which factor is affected in haemophilia A due to which gene
Factor VIII
F8 gene on X chromosome
Which factor is effected in Haemophilia B due to which gene
Factor IX
F9 gene on X chromosome
Which haemophilia type is more common
Haemophilia A
What type of disease is haemophilia
X linked Recessive
What is the treatment for deep thrombosis
Warfarin
