Haematopoetic components Flashcards
where does erythropoiesis (red blood cell production) occur
bone marrow (pluripotent stem cells)
what do pluripotent stem cells develop to
Myeloid progenitor (become blood cells)
or
lymphoid progenitor (become lymphoid cells)
what is the function of erythrocytes
contain haemoglobin that bind to oxygen and carry it around the body.
and carry carbon dioxide for excretion
which cells produces platelets
megakaryocyte
what are reticulocytes
immature red blood cells
what are functions of neutrophils
tissue repair
phagocytic
which blood cell is not found in the blood
macrophages
how are macrophages developed
monocytes leave the blood and develop into macrophages in tissue
how to identify eosinophils under the microscope
very pink due to staining
function of eosinophils
helminth (soil transmitted) infection
allergy
most abundant white blood cells
neutrophils
how to identify monocytes
large nucleus
human kidney shape
how to identify basophils
large cytoplasmic granules that block the nucleus
not very abundant
what are the functions of mast cells
release histamines (activating factors) for wound release
what percentage of white blood cells are neutrophils
60%
what percentage of white blood cells are lymphocytes
30%
how to identify lymphocytes
very large nucleus
circular
what is the adaptive immune system
specialised lymphocytes
where are T lymphocytes developed
Thymus
where are B lymphocytes mature
Bone marrow and Lymph nodes
Bursa of Fabricus in birds
What hormone stimulates erythrocyte production
erythropoietin
which are the primary lymphoid organs
thumus
bone marrow (bursa of fabricius in birds)
which are the secondary lymphoid organs
spleen
lymph nodes
tonsils
what are tertiary lymphoid organs
ectopic tissue that develops at site of chronic inflammation
what are the lobules of the thymus
cortex
medulla
when is the thymus most active
early life to make the most immune cells
what are the functions of the spleen
white pulp: surveys the blood that flows through for foreign antigens
red pulp: filters + removes damaged or aged red blood cells by phagocytosis
what is the purpose of the spleen trabeculae
for contraction so spleen can push out erythrocytes
where are B cells localised in lymph nodes
follicles
what occurs in the paracortex of lymph nodes
T cells are localised
how to lymphocytes get from lymph nodes to the blood
efferent lymphatic
name the 5 palpable lymph nodes
submandibular
pre scapula
axillary
inguinal
popliteal
what is Gut Associated Lymphoid tissue
mucosal membrane that is exposed to the environment
(secondary lymphoid tissue)
