Lymphocytes and CD Markers

Question 1

T-cell surface marker: Rosette with sheep red blood cells (SRBCs)

Answer 1

CD2+

Question 2

T-cell surface marker: Associated with T-cell receptor (TCR)

Answer 2

CD3+

Question 3

T Helper Cell Surface Marker

Answer 3

CD4+

Question 4

Cytotoxic T Cell / Regulatory Cell Surface Marker

Answer 4

CD8+

Question 5

Surface maker for B cells (CD)

Answer 5

CD19+, CD20+, CD21+

Question 6

CD markers for NK cells

Answer 6

CD16+, CD56+

Question 7

What is the function of CD4 cells?

Answer 7

T helper cells: release cytokines and become memory cells

Interact with B cells

Question 8

What is the function of CD8 cells?

Answer 8

Become cytotoxic

Interact with B cells

Question 9

What is the function of B cells?

Answer 9

Evolve into plasma cells to secrete antibodies

Become memory cells

Question 10

What is the function of NK cells?

Answer 10

Killing virus-infected cells and tumor cells

Question 11

Do NK cells possess T-cell receptor and/or surface immunoglobulin?

Answer 11

No

Question 12

What type of T-cell receptors are found on T-cells?

Answer 12

TCR-1 or TCR-2

Question 13

What % of T cells make up total % of circulating lymphoid cells?

Answer 13

~ 80%

Question 14

What % of B cells make up total % of circulating lymphoid cells?

Answer 14

5-15%

Question 15

What % of NK cells make up total % of circulating lymphoid cells?

Answer 15

5-15%

Question 16

What type of receptors are found on the surface of B cells AND monocytes?

Answer 16

Surface immunoglobulins (IgM or IgG) and complement receptors

Question 17

What is the normal T cell:B cell ratio?

Answer 17

8:1

Question 18

What is the normal CD4:CD8 ratio? (T helper : T cytotoxic/regulatory ratio)

Answer 18

2:1

Question 19

In an AIDs patient, what is the CD4:CD8 ratio (Helper T cell : Cytotoxic T cell ratio)

Answer 19

1:2