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QIHC maryjw79 @ gmail email 4 access > IHC General Markers > Flashcards

IHC General Markers Flashcards

1
Q

PSA

A

prostatic epithelium
(prostate-specific antigen)

used to follow prostate carcinoma
can also be elevated in BPH and prostatitis

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2
Q

Prostatic acid phosphatase

A

prostate carcinoma

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3
Q

CEA

A

Carcinoembryonic antigen

very nonspecific but produced by ~70% of colorectal and pancreatic cancers

also produced by gastric, breast, and medullary thyroid carcinomas

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4
Q

a-fetoprotein

A

normally made by fetus

hepatocellular carcinomas

nonseminomatous germ cell tumor (ie: testis, ovary)

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5
Q

B-hCG

A

Gydatidiform moles

choriocarcinomas

gestational trophoblastic disease

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6
Q

CA-125

A

ovarian cancer

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7
Q

S-100

A

melanoma, neural tumors, schwannomas

pathoma + langerhans cell histiocytosis

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8
Q

alkaline phosphatase

A

metastases to bone, liver

paget’s disease of bone

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9
Q

TRAP

A

tartrate-resistant acid phosphatase (TRAP)

hairy cell leukemia (B-cell neoplasm)

“TRAP the hairy animal”

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10
Q

CA-19-9

A

pancreatic adenocarcinoma

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11
Q

calcitonin

A

medullary thyroid carcinoma

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12
Q

keratin

A

epithelium

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13
Q

vimentin

A

mesenchyme

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14
Q

desmin

A

muscle

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15
Q

GFAP

A

neuroglia

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16
Q

neurofilament

17
Q

ER

A

breast epithelium

18
Q

thyroglobulin

A

thyroid follicular cells

19
Q

chromogranin

A

neuroendocrine cells

(small cell carcinoma of lung and carcinoid tumors)

20
Q

MPO

A

AML
(myeloid blasts)

Adults

21
Q

TdT

A

ALL
(lymphoblasts)

Children

22
Q

CD34+

A

Hematopoietic stem cell

23
Q

Markers of B-ALL

A

TdT+

CD10, CD19, CD20

24
Q

Markers of T-ALL

A

TdT+

CD2-8

25
Q

Auer rods

26
Q

Markers of CLL

A

CD5 and CD20

Naive B cells

27
Q

Lytic bone lesions

WITH OR WITHOUT RASH

A

WITH: ATLL (mature CD4)

W/O: multiple myeloma

28
Q

Markers of Hodgkin Lymphoma

A

Reed-Sternberg cells

CD15 and CD30

29
Q

Markers of langerhans cells

A

CD1a+ and S100+

30
Q

Melanoma

A

Melan-A, S-100, PNL2, tyrosinase

31
Q

Thyroid carcinoma (epithelial)

A

Thyroglobulin (+)

32
Q

Thyroid carcinoma (c-cell)

A

Synaptophysin (+)
Chromogranin (+)
Thyroglobulin (-)

33
Q

MCT

A

Vimentin (+)
Tryptase (+)
CD117 (KIT) (+)
Chymase (+/-)
MCP-1 (+)
IL-8 (+)

34
Q

Differentiate between canine urinary bladder transitional cell carcinoma and other carcinomas

A

Uroplakin III

35
Q

Confirm a diagnosis of hemophagocytic histiocytic sarcoma

36
Q

Positive markers with hemangiosacoma

A

Factor 8 (vWF)
CD31

37
Q

GIST

A

CD117 (KIT)
CD34
DOG-1
S-100

38
Q

Distinguish pheochromocytoma from adrenocortical carcinoma

A

chromogranin A
synaptophysin

39
Q

Progressive histiocytosis

A

CD1a
CD11c/CD18
CD5
Iba-1
CD204

QIHC maryjw79 @ gmail email 4 access (16 decks)

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