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Cell Bio III > Lymphatic tissue and organs > Flashcards

Lymphatic tissue and organs Flashcards

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1
Q

What are the primary lymphatic tissues?

A
  1. Bone marrow

2. Thymus

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2
Q

What occurs at primary lymphatic tissues?

A

Development and maturation of lymphocytes into immunocompetent cells

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3
Q

What are the secondary lymphatic tissues?

A
  1. Lymph nodes
  2. Mucosa-associated lymphatic tissue (MALT)
  3. Spleen
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4
Q

What occurs at secondary lymphatic tissues?

A

Formation of immunological defense against antigens or pathogens; confrontation with antigens or pathogens

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5
Q

MALT consists of what other lymphatic regions?

A
  1. GALT (gut-associated lymphatic tissue)
  2. BALT (bronchus-associated lymphatic tissue)
  3. GU tract
  4. Tonsils
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6
Q

In which layer of the epithelium is GALT located?

A

Lamina propria

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7
Q

What are characteristics of diffuse lymphatic tissue (MALT)?

A
  1. Not sharply delineated
  2. Part of some other organ, often sprinkled through lamina propria
  3. Reticular fibers provide framework for cell suspension
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8
Q

Which cells are found in diffuse lypmhatic tissue?

A

Lymphocytes, monocytes, macrophages, plasma cells

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9
Q

What are characteristics of lymphatic nodules (follicles)?

A
  1. Non-encapsulated, spherical, dense aggregations of lymphocytes with SOME organization
  2. May be primary or secondary
  3. May be solitary or aggregate structures
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10
Q

What are characteristics of primary lymphatic nodules?

A

Appear homogeneous throughout, have mostly small lymphocytes

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11
Q

What are characteristics of secondary lymphatic nodules?

A

Have two zones - corona (mantle) zone and germinal center

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12
Q

What is the mantle zone?

A

The outer, dark-staining zone containing mature (small) lymphocytes in a secondary lymphatic nodule

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13
Q

What is the germinal center?

A

The inner, light-staining zone containing immature (medium and large) lymphocytes in a secondary lymphatic nodule

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14
Q

What happens to a secondary lymphatic nodule when an antigen is encountered?

A

Germinal center starts to swell

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15
Q

Are solitary lymphatic nodules temporary or permanent?

A

Temporary - may appear and reappear at a particular site

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16
Q

Are lymphatic aggregates temporary or permanent?

A

Permanent

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17
Q

What are examples of lymphatic aggregates?

A
  1. Peyer’s patches in the ileum
  2. Lymphatic tissue in the appendix (lamina propria and submucosa)
  3. BALT in respiratory tract
  4. Lymphatic nodules in tonsils, lymph nodes, spleen
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18
Q

The tonsils have what kind of lymphatic tissue organization?

A

Aggregations of lymphatic nodules

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19
Q

What type of lymphocyte predominates in the tonsils?

A

B lymphocyte

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20
Q

What kind of epithelium covers the pharyngeal tonsils?

A

Pseudostratified columnar epithelium with cilia

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21
Q

Do the pharyngeal tonsils have crypts?

A

No

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22
Q

What do the pharyngeal tonsils have instead of crypts?

A

Pleats

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23
Q

What kind of epithelium covers the palatine tonsils?

A

Stratified squamous nonkeratinized infiltrated by B cells

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24
Q

Do the palatine tonsils have crypts?

A

Yes

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25
Q

Where are B cells produced in the palatine tonsils?

A

Germinal centers found in the nodules

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26
Q

What kind of epithelium covers the lingual tonsils?

A

Stratified squamous nonkeratinized

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27
Q

Do the lingual tonsils have crypts?

A

Yes

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28
Q

What are lymph node trabeculae?

A

CT septa that extend from capsule into lymph node carrying vessels and nerves

29
Q

What are characteristics of subcapsular sinuses?

A

Deep to CT capsule, drain into trabecular sinuses

30
Q

What are characteristics of trabecular sinuses?

A
  1. Separate nodules from trabeculae
  2. Drain into medullary sinuses
  3. Lined by endothelial cells - allow lymphatic cells to enter or exit
  4. Contain reticular cells
31
Q

Which lymph sinuses are lined by macrophages?

A

All sinuses

32
Q

What are the cells of the reticular meshwork?

A
  1. Reticular cells
  2. Dendritic cells
  3. Macrophages
  4. Follicular dendritic cells
33
Q

What is the reticular tissue?

A

Consists of reticular cells and reticular fibers which form a fine 3D meshwork that suspends the cells and sinuses and supports lymph node contents

34
Q

What is the function of the reticular cells?

A

Synthesize and secrete type III collagen. Cytoplasmic processes wrap around reticular fibers to isolate them from lymphatic tissue parenchyma

35
Q

What is the function of dendritic cells in a lymph node?

A

Ag presentation

36
Q

What is the function of macrophages in lymph nodes?

A

Ag presentation, phagocytic

37
Q

What is the function of follicular dendritic cells in lymph nodes?

A

Bind Ag-Ab complexes

38
Q

What comprises the parenchyma of a lymph node?

A
  1. Cortex
  2. Paracortex
  3. Medulla
39
Q

What type of lymphatic tissue organization is found in the cortex of the lymph node?

A

Nodules

40
Q

What type of lymphocyte is found in the cortex of the lymph node?

A

B cell

41
Q

What type of cells are found in the germinal center of the lymph node nodules?

A

Dendritic reticular cells

42
Q

What type of lymphocyte is found in the paracortex of a lymph node?

A

T cell

43
Q

Are nodules primary or secondary?

A

Secondary

44
Q

Are nodules permanent or temporary?

A

Permanent

45
Q

What part of the lymph node is thymus-dependent?

A

Paracortex

46
Q

What are high endothelial venules?

A
  1. Located in the paracortex
  2. Lined with simple cuboidal to columnar epithelium
  3. B and T cells escape from bloodstream via HEVs to enter paracortex (B cells keep going to cortex)
47
Q

What percentage of lymphocytes enter the lymph node via the HEVs of the paracortex?

A

90%

48
Q

What are medullary cords?

A

Irregularly shaped clumps of cells containing B, T, plasma, and dendritic cells and macrophages

49
Q

What is the role of the thymus?

A

Site where T cells mature

50
Q

In what part of the thymus do T cells mature?

A

Cortex

51
Q

What type of cells form the framework of the thymus?

A

Epithelioreticular cells

52
Q

What are the functions of Type 1 epithelioreticular cells?

A
  1. Form seal around cortex to separate it from CT capsule and trabeculae
  2. Form sleeve around tunica adventitia of vessels
  3. Form tight junctions to seal thymic cortex from rest of the body
53
Q

What is the function of Type 2 epithelioreticular cells?

A
  1. Form meshwork in midcortex
  2. Held together by desmosomes
  3. “Teachers” of thymic cell education
54
Q

What is the function of Type 3 epithelioreticular cells?

A
  1. Protein synthesis

2. Form tight junctions; seal between cortex and medulla

55
Q

What is the function of Type 4 epithelioreticular cells?

A

Barrier at corticomedullary junction

56
Q

What is the function of Type 5 epithelioreticular cells?

A

Meshwork / framework of medulla

57
Q

What is the function of Type 6 epithelioreticular cells?

A

Form Hassall’s corpuscles

58
Q

What are Hassall’s corpuscles?

A

Made of Type 6 epithelioreticular cells - they are concentric, eosinophilic whorls that are unique to thymic medulla. They exhibit keratinization

59
Q

Where do mature T cells go once mature?

A

Enter bloodstream from medulla via postcapillary venules to take up residence in paracortex of lymph nodes and PALS of spleen

60
Q

What makes up the blood-thymus barrier (inside-out)?

A
  1. Endothelium
  2. Basal lamina
  3. Macrophages
  4. Type 1 epithelioreticular cells
61
Q

What is DiGeorge’s syndrome?

A

Individuals cannot produce T cells, may die from infection or tetany

62
Q

Does the thymus have afferent lymphatic vessels?

A

No

63
Q

What makes up the white pulp of the spleen?

A
  1. Periarterial lymphatic sheath

2. Splenic nodules

64
Q

What are the characteristics of the periarterial lymphatic sheath?

A
  1. Thymus-dependent zone of the splenic pulp
  2. Contains T cells
  3. Central artery is centrally located within PALS
65
Q

What are the characteristics of the splenic nodules?

A
  1. Lymphatic nodules
  2. Contain B cells
  3. May contain germinal center around central artery
  4. Central artery is eccentrically located in nodule
66
Q

What makes up the red pulp of the spleen?

A
  1. Splenic cords

2. Splenic sinuses

67
Q

What are the Cords of Billroth?

A
  1. Irregular and branching cords of splenic tissue
  2. Contain loose network of reticular cells and fibers
  3. Spaces between fibers are filled with blood to be filtered
  4. Filter blood
  5. Contain macrophages, plasma cells, dendritic cells
68
Q

What are the splenic sinuses?

A
  1. Lined by endothelial cells with wide intercellular spaces to allow blood cells to pass in and out of sinuses
  2. Drain into pulp veins which in turn drain into trabecular veins

Cell Bio III (10 decks)

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