Lymphatic System Flashcards

1
Q

What are the organs of the lymphatic system?

A
  • Spleen
  • Thymus
  • Lymph Vessels
  • Lymph Nodes
  • Tonsils
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2
Q

What are functions of the lymphatic system?

A

Produce, maintain and distribute lymphocytes and lymphoid cells that provide defence against infection and foreign substances

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3
Q

What are components of the lymphatic system?

A
  • Lymph
  • Lymphatic vessels
  • Lymphoid cells
  • Lymphoid tissues
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4
Q

Describe lymph

A

Fluid that resembles plasma

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5
Q

Describe lymphatic vessels

A

Begin in peripheral tissues, connected to veins

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6
Q

What are examples of lymphoid cells?

A

Lymphocytes and phagocytes

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7
Q

Describe lymphoid tissues in primary and secondary responses

A

Primary
-Sites where lymphocytes form and mature
Secondary
-Sites where lymphocytes are activated

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8
Q

Describe circulation of fluid in the lymphatic system

A

-Lymphatic vessels carry lymph from peripheral tissues to venous system
Peripheral Tissues —> Lymphatic Capillaries –> Lymphatic Vessels/Ducts —> Subclavian vein

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9
Q

What are lymphocytes?

A

Responds to abnormal body cells, eliminate threat through physical & chemical attack

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10
Q

What are phagocytes?

A

Cells that perform phagocytosis

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11
Q

Describe role of immunity the the lymphatic system

A

Ability to resist infection and disease

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12
Q

What is an antigen?

A

Substance capable of inducing an immune response (bacteria, foreign object)

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13
Q

What is a pathogen?

A

A disease causing organism

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14
Q

What is phagocytosis?

A

“Cell eating”: engulfing cellular debris or foreign material

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15
Q

What is an antibody?

A

A protein produced by plasma cells that binds to specific antigen and promotes destruction and removal from body

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16
Q

What are the general innate (non-specific) immunity defences?

A
  • First line of defence: physical barriers
  • Phagocytes
  • Immune surveillance
  • Interferon
  • Inflammation
  • Complement system
  • Fever
17
Q

Describe the role of a physical barrier

A
  • Slow entry of infections into body
  • Internal defence processes attack infectious organisms if they enter
  • Keep hazardous organisms outside
18
Q

Describe the role of immune surveillance

A
  • Continuous policing of peripheral tissues by natural killer cells
  • Destroys cells that has antigen, including own abnormal cells
19
Q

Describe the role of interferons

A

Small proteins released by activated lymphocytes and macrophages

20
Q

Describe the role of inflammation

A
  • Localised tissue response to injury
  • Prevent additional pathogens from entering wound
  • Slow spread of pathogens from injury sites
21
Q

Describe the complement system

A

Complement proteins kill pathogens, enhance phagocytes and inflammation

22
Q

What is a fever?

A

Moderate increase in body temperature

23
Q

What is adaptive (specific) immunity?

A

Involve T and B cells that responds to specific antigen

24
Q

What are cytotoxic T-cells?

A

Attack foreign cells attacked by viruses

25
What are helper T-cells?
Stimulate activation and function of T cells and B cells
26
What are regulatory T-cells?
Moderate activity of T and B cells
27
What are memory T-cells?
Respond to previously encountered antigen
28
What are B-cells?
Differentiate into plasma cells which produce antibodies
29
What is cell-mediated immunity?
Defends against abnormal cells/cells with pathogens
30
What is antibody-mediated immunity?
Defends against antigens and pathogens in body fluids
31
What are the four general characteristics of adaptive (specific) immunity?
1) Specificity 2) Versatility 3) Tolerance 4) Memory
32
Describe specificity in adaptive (specific) immunity?
A specific antigen activates a specific immune response
33
Describe versatility in adaptive (specific) immunity?
Large diversity of T and B cells in body: response to a large range of antigens
34
Describe tolerance in adaptive (specific) immunity?
- Responds to all cells capable of inducing an immune response - Immune system tolerates antigens on healthy cells
35
Describe memory in adaptive (specific) immunity?
- Activation of T and B cells involves repeated cycles * 1 group attacks antigens * 1 group remains inactive
36
Describe a primary response to antigens
Initial immune response to antigen
37
Describe a secondary response to antigens
- Extensive and prolonged immune response: due to presence of memory cells * Takes time to develop because antigen must activate appropriate B cells * When exposed to antigen 2nd time, immediately secrete huge amounts of antibodies
38
Summarise the types of cells that are involved in innate (nonspecific) immunity
``` Neutrophils -Phagocytosis Macrophages -Phagocytosis Natural Killer (NK) Cells -Immune surveillance, kill abnormal/foreign cells via release of perforin Mast Cells -Release histamine to promote inflammation ```