Lymphatic System Flashcards

1
Q

What are the primary organs of the lymphatic system?

A

generate lymphocytes from progenitor cells
bone marrow
thymus
cloacal bursa

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2
Q

What are the secondary organs of the lymphatic system?

A

site of lymphocyte activation
lymph nodes
spleen
mucosal associated lymphoid tissue

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3
Q

What is the function of the lymphatic system?

A

to protect the body against pathogenic organisms

removal and disposal of cells

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4
Q

What are the actions the lympathic system is involved in?

A
  • phagocytosis via macrophages

- production of immunologically competent cells such as antigen presenting cells and T and B cells

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5
Q

What is the mononuclear phagocytic system?

A

fixed macrophages and free macrophages

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6
Q

What are fixed macrophages?

A

sinusoids of liver, spleen and lymph nodes

reticulum of bone marrow

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7
Q

What are free macrophages?

A

blood, lung and serous cavities

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8
Q

How does T cell differentiation come about?

A

bone marrow, lymphoid stem cell

Thymus

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9
Q

How does B cell differentiation come about?

A

bone marrow, lymphoid stem cell

bursa or bone marrow

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10
Q

What are the cells of the lymphatic system?

A

lymphocytes
antigen presenting cells
stromal cells

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11
Q

T or F: T and B cells originate from secondary lymphatic organs?

A

False, PRIMARY

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12
Q

Where do T cells migrate to from bone marrow?

A

thymus

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13
Q

T or F: B cells mature in bone marrow?

A

True

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14
Q

What is the cloacal bursa of birds?

A

functionally the same to mammalian bone marrow for B cell differentiation

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15
Q

Where is the thymus located?

A

medastinium, cranial to heart

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16
Q

What is the thymic cortex?

A

stains darker than medlla
greater number of lympocytes present
area of positive selection
macrophages

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17
Q

What is the thymic medulla?

A

contains epithelial reticular cells
negative selection
form Hassals corpuscles

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18
Q

What are Hassals corpuscles?

A

large central calcified cells surrounded by circles of keratinized cells

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19
Q

Is the thymic cortex or medulla more tightly compact?

A

cortex

20
Q

What is the blood supply in the thymus?

A

arteries enter at corticomedullary junction within connective tissye
divide into arteriolies
branch into capillary network in cortex

21
Q

What are educated T cells?

A

leave thymus

enter blood, settle in T cell areas of secondary lymphatic tissue

22
Q

What is the function of lymph nodes?

A

filter antigens from lymph before returning it to blood stream

23
Q

T or F: lymph nodes have both efferent and afferent lymph vessels

A

True

24
Q

What are the three parts of a lymph node?

A

capsule
cortex
medulla

25
Q

What is a lymph node cortex comprised of?

A

primary and secondary follices
paracortical tissue
endothelial blood vessels

26
Q

What is a lymph node medulla made up of?

A

cords and sinus

27
Q

What is a hilus?

A

indentation in a lymph node where arteries enter and efferent lymphatics and veins leave

28
Q

What is a lymph node stroma?

A

reticular cells and fibers that support lymphocytes,macrophages and plasma cells

29
Q

T or F: most lymphocytes migrate through lymph nodes from peripheral blood

A

True

30
Q

What is the function of the spleen?

A
filters blood 
recovers and stores iron
removes antigens from blood
immune response against blood borne anitgens 
B and T cells 
stores RBC and platelets
31
Q

T or F: cats do not have storage type spleen?

A

True

32
Q

What is a spleens structure?

A

outer capsule=dense connective tissue
capsule=trabeculae=collagen, elastic, smooth
each trabeculae contain vein and artery

33
Q

What is white pulp?

A

part of spleen that contains central arterioles and follicles

34
Q

What is red pulp?

A

part of spleen that contains sinusoids

35
Q

What are the two parts of the red pulp of the spleen?

A

parenchyma and venous sinuses

36
Q

What is the parenchyma made up of?

A

macrophages and blood cells

B cells and T cells

37
Q

How does splenic blood flow work?

A

in at central artery, branches to form pencillary arteries, end in capillaries, blood enters parenchyma, then to sinus system, sinuses become larger, then into splenic vein into hepatic portal vein

38
Q

What is GALT?

A

Gut associated lymphatic tissue

39
Q

What are peyers patches?

A

aggregated lymphatic nodules

B cells maturation

40
Q

What are M cells?

A

specialized epithelial cells that cover peyers patches

41
Q

What is BALT?

A

bronchiolar associated lymphoid tissue

42
Q

What are tonsils?

A

aggregated lymphatic nodules in pharynx

no afferent vessels

43
Q

Where does local production of antibodies occur?

A

tonsils

44
Q

What are lympathic vessels?

A

lined by endothelial cells

absorb fluid from intersituoum, and pass it back to blood stream

45
Q

Where are lympathic vessels NOT found?

A
eye 
cartilage 
bone or bone marrow
spleen
CNS