Lymphadenopathy and Splenomegaly II Flashcards
factor XIII
cross linked fibrin clot
PFA
platelet function analyzer
looks at platelet function
drugs and platelets
aspirin and NSAIDS
clopidogrel, abcixumab
platelet quality disorder
vWD
drugs
inherited disorders
ristocetin
look at vWD
vWD
factor VIII may be decreased
type 2N vWD
auto recessive
-all vWF factors are normal
and will have decreased factor VIII
joint swelling and bruising in infant, deep thigh hematomas take few weeks to heal, pale, tenderness of ankles, no rash, elevated PTT
Hem A
-x-linked recessive disease
PTT
intrinsic
V, VIII, IX, X, XI, XII, PT, fibrinogen
PT
extrinsic
V, VII, X, PT, fibrinogen
heparin
normal PT, prolonged PTT
differentiate between factor deficiency and factor inhibitor problem?
mixing studies - mix with normal plasma
-should correct back to normal PTT if deficiency
if not - inhibitor present
Hem A
factor VIII
Hem B
factor IX
type 2N vWD
low factor VIII
important family hx about x-linked recessive
males on mother side of family
bleeding after minor cut
more likely platelet problem
large hematomas
more with hemophilia
long bleeding time and long PTT
vWD and Hem A (factor VII)
asymptomatic patient with thrombocytopenia, what to do
recheck it
pseudo-thrombocytopenia
clumping of platelets due to EDTA
symptomatic thrombocytopenia
10-20,000 platelets
decreased platelet production
virus, chemo, BM aplasia, alcohol toxicity, B12/folate deficiency
increased destruction platelets
ITP, drugs, autoimmune, MAHA (DIC, TTP, HUS), virus, HELLP
