Lymphadenopathy and Splenomegaly II

Question 1

factor XIII

Answer 1

cross linked fibrin clot

Question 2

PFA

Answer 2

platelet function analyzer

looks at platelet function

Question 3

drugs and platelets

Answer 3

aspirin and NSAIDS

clopidogrel, abcixumab

Question 4

platelet quality disorder

Answer 4

vWD
drugs
inherited disorders

Question 5

ristocetin

Answer 5

look at vWD

Question 6

vWD

Answer 6

factor VIII may be decreased

Question 7

type 2N vWD

Answer 7

auto recessive
-all vWF factors are normal

and will have decreased factor VIII

Question 8

joint swelling and bruising in infant, deep thigh hematomas take few weeks to heal, pale, tenderness of ankles, no rash, elevated PTT

Answer 8

Hem A

-x-linked recessive disease

Question 9

PTT

Answer 9

intrinsic

V, VIII, IX, X, XI, XII, PT, fibrinogen

Question 10

PT

Answer 10

extrinsic

V, VII, X, PT, fibrinogen

Question 11

heparin

Answer 11

normal PT, prolonged PTT

Question 12

differentiate between factor deficiency and factor inhibitor problem?

Answer 12

mixing studies - mix with normal plasma
-should correct back to normal PTT if deficiency

if not - inhibitor present

Question 13

Hem A

Answer 13

factor VIII

Question 14

Hem B

Answer 14

factor IX

Question 15

type 2N vWD

Answer 15

low factor VIII

Question 16

important family hx about x-linked recessive

Answer 16

males on mother side of family

Question 17

bleeding after minor cut

Answer 17

more likely platelet problem

Question 18

large hematomas

Answer 18

more with hemophilia

Question 19

long bleeding time and long PTT

Answer 19

vWD and Hem A (factor VII)

Question 20

asymptomatic patient with thrombocytopenia, what to do

Answer 20

recheck it

Question 21

pseudo-thrombocytopenia

Answer 21

clumping of platelets due to EDTA

Question 22

symptomatic thrombocytopenia

Answer 22

10-20,000 platelets

Question 23

decreased platelet production

Answer 23

virus, chemo, BM aplasia, alcohol toxicity, B12/folate deficiency

Question 24

increased destruction platelets

Answer 24

ITP, drugs, autoimmune, MAHA (DIC, TTP, HUS), virus, HELLP

Question 25

other causes of thrombocytopenia

Answer 25

dilution

sequestration

Question 26

methotrexate

Answer 26

affects folic acid metabolism

bone marrow suppression

Question 27

tests to rule out DIC

Answer 27

PT, PTT, fibrinogen

everything used up

fibrinogen used up - factor 2

Question 28

ITP

Answer 28

idiopathic thrombocytopenia
-diagnosis of exclusion

most common cause of outpatient thrmbocytopenia

Question 29

haptoglobin

Answer 29

decreased with hemolysis

Question 30

D dimer

Answer 30

good as a negative test

Question 31

vascular abnormality

Answer 31

order ANCA test

Question 32

leukocytoclastic vasculitis

Answer 32

wegeners

with elevated C-ANCA

Question 33

birth control pill

Answer 33

procoagulant

Question 34

hypercoagulable

Answer 34

factor V, protein C, S, antithrombin III deficient

birth control pills

cancer, pregnancy, trauma, surgery, immobilization, ati-phospholipid syndrome - secondary

Question 35

excess pro-thrombotic factors

Answer 35

factor V

prothrombin

Question 36

deficient anti-thrombotic factors

Answer 36

AT III
protein C
protein S

Question 37

clotting tx

Answer 37

hx of 2 clots

-get anticoag for life

Question 38

both arterial and venous effected

Answer 38

antiphospholipid syndrome