Antineoplastic Agents III

Question 1

steroid hormones

Answer 1

antilymphocytic effect

common combo therapy

Question 2

imatinib

Answer 2

protein tyrosine kinase inhibitor

inhibits tyrosine kinase domain of BCR-ABL oncoprotein

hepatic metabolism CYP 450

Question 3

tx of CML

Answer 3

with t(9;22)

imatinib

Question 4

dasatinib

Answer 4

also used for 9;22 CML

protein tyrosine kinase inhibitor

Question 5

trastuzumab

Answer 5

monoclonal antibody

Question 6

MOA trastuzumab

Answer 6

binds to Her2/neu and inhibits intracellular signaling for proliferation

Question 7

breast cancer

Answer 7

her2/neu

tx trastuzumab

Question 8

cardiotoxicity

Answer 8

trastuzumab

Question 9

CD20

Answer 9

non-hodgkin lymphoma

rituximab
ibritumomab
tositumomab

Question 10

CD52

Answer 10

CLL

alemtuzumab

Question 11

CD33

Answer 11

AML

gemtuzumab

Question 12

HER2/neu

Answer 12

breast cancer

trastuzumab

Question 13

EGFR

Answer 13

colorectal, lung, pancreatic, breast cancer

cetuximab

Question 14

VEGF

Answer 14

colorectal lung cancer

bevacizumab

Question 15

vaccines

Answer 15

can reduce burden of cancer

therapeutic or prophylactic

Question 16

cisplatin

Answer 16

platinum coordinate complex

considered alkylating agent

Question 17

cyclphosphamide

Answer 17

nitrogen mustard - alkylating agent

Question 18

ifosfamide

Answer 18

nitrogen mustard - alkylating agent

Question 19

busulfan

Answer 19

alkyl sulfonate - alkylating agent

Question 20

antimetabolites

Answer 20

CCS - s phase

Question 21

epipodophyllotoxins

Answer 21

CCS - s-g2 phase

Question 22

vinca alkaloids

Answer 22

CCS m phase

Question 23

taxanes

Answer 23

CCS - m phase

Question 24

camptothecins

Answer 24

CCS - S phase

Question 25

bleomycin

Answer 25

CCS - G2-M phase

Question 26

alkylating agents

Answer 26

CCNS

Question 27

anthracyclines

Answer 27

CCNS

Question 28

platinum analogs

Answer 28

CCNS

Question 29

burkitt lymphoma

Answer 29

high growth fraction

curable with chemo

Question 30

colorectal carcinoma

Answer 30

low growth fraction

minor chem activity

Question 31

ATP dependent transporter

Answer 31

anthracyclines
vinca alkaloids
etoposide
paclitaxel
dactinomycin

Question 32

ondansetron

Answer 32

for nausea/vomiting

Question 33

alkylating agent MOA

Answer 33

covalent link with DNA

inter or intra strand

Question 34

pulmonary fibrosis

Answer 34

busulfan

Question 35

antimetabolites

Answer 35

CCS - S phase

methotrexate, 5-FU, 6-mercaptopurine

Question 36

inhibits dihydrofolate reductase

Answer 36

methotrexate

cancer, rheumatoid arthritis, psoriasis

Question 37

leucovorin

Answer 37

rescue normal cells from high dose methotrexate

reduced folate can bypass DHFR

Question 38

stabilize microtubules

Answer 38

taxanes

Question 39

inhibit microtubule assembly

Answer 39

vinca alkaloides

Question 40

type I topoisomerase inhibitors

Answer 40

cut one strand of dsDNA

camptothecins

Question 41

type II topoisomerase inhibitors

Answer 41

cut both strands of dsDNA

etoposide, doxorubicin

Question 42

all anticancer antiboitics products of

Answer 42

streptomyces species of bacteria

Question 43

dysrhythmia and heart failure

Answer 43

anthracyclines - doxorubicin

Question 44

contraindicated with HIV positive and CD0 DLBCL

Answer 44

vinblastine

Question 45

confusion

Answer 45

asparaginase

Question 46

parasthesias

Answer 46

vincristine