Lymphadenopathy and Splenomegaly I Flashcards
enlargment of lymph node
proliferation of WBCs
abnormal lymph nodes
adults - larger than 1-2 cm
except groin where can be bigger normally
lymphadenopathy
larger, painful, abnormal to touch
local lymphadenopathy
reflects area they drain
virchows node
left supraclavicular lymph node
abdominal malignancy**
supraclavicular nodes
drain from abdomen and chest
high risk for malignancy
axillary nodes
drain arm, thoracic wall, and breast
silicone breast implants
may cause supraclavicular and axillary lymphadenopathy
epitrochlear nodes
elbow fossa
infections of forearm and hand
inguinal lymph nodes
lower extremity infection
-STDs
and cancer
mesenteric nodes
around bowels
-appendicitis, cholecystitis, divertiulitis, whipples disease
neoplasm
IBS, panniculitis
retroperitoneal nodes
kidney cancer
panniculitis
inflammation of subQ adipose tissue
nontender, axillary, cervical, occipital nodes - generalized lymphadenopathy
check for HIV
during second week of acute HIV infection
-nodes then decrease in size but modest degree of adenopathy persists
nontender enlarged scrofula (neck) nodes over weeks to months without systemic symptoms
mycobacterial infection
m. tuberculosis in adults
children - mycobacterium avium complex or m. scrofulaceum
fever, pharyngitis, lymphadenopathy with symmetric enlargement, posterior cervical, axillary, inguinal
infectious mononucleosis
lymphadenopathy peaks first week and subsides over 2-3 weeks
soft, nontender lmyph nodes cervical axillary and inguinal
SLE
phenytoin
can cause lymphadenopathy
castleman disease
massive lymphadenopathy with fever, hepatomegaly, splenomegaly, polyclonal hypergammaglobulinemia
kikuchi disease
rare, unknown cause
young women
cervical lymphadenopathy or fever
kawasaki disease
childhood vasculitis
cervical lymphadenopathy with fever, conjunctivitis, mucositis, strawberry tongue, rash, coronary a aneurysms
strawberry tongue
mucositis in kawasaki disease
angioimmunoblastic T lymphoma
lymphadenopathy
inflammatory pseudotumor
lymphadenopathy and systemic symptoms
-biopsy - fibrosing and inflammatory process
amyloidosis
amyloid deposits systemically
occasionally deposited in nodes
kimura disease
inflammation of subQ and lymph nodes of head and neck
undercooked meat
toxoplasmosis
tick bite
lyme disease
hard nodes
cancers that induce fibrosis
firm rubbery nodes
lymphomas and chronic leukemias
heterophile test
mono - EBV
monospot test
PPD
TB test
RPR test
syphilis
ANA test
autoimmune disease
best for diagnosis
open biopsy
fine need aspiration for cytology
most useful when searching for recurrence of cancer
areas where open biopsy is not available
congestive splenomegaly
cirrhosis
heart failure
thrombosis of portal, hepatic, or splenic veins
felty syndrome
rheumatoid arthritis and splenomegaly
adult complaining of post-bath pruritis with ruddy complexion and splenomegaly
polycythemia vera
