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HEME/LYMPH Exam 2 > Antineoplastic Agents I > Flashcards

Antineoplastic Agents I Flashcards

1
Q

cyclophosphamide

A

nitrogen mustard

-alkylating agent

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2
Q

ifosfamide

A

nitrogen mustard

-alkylating agent

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3
Q

busulfan

A

alkyl sulfonate

-alkylating agent

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4
Q

cisplatin

A

platinum coordinate complex

-alkylating agent

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5
Q

methotrexate

A

folic acid analog

-antimetabolite

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6
Q

fluorouracil

A

5-FU
pyrimidine analog
-antimetabolite

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7
Q

mercaptopurine

A

6-MP
purine analog
-antimetabolite

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8
Q

vinblastine

A

vinca alkaloid

-natural product

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9
Q

vincristine

A

vinca alkaloid

-natural product

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10
Q

paclitaxel

A

taxane

-natural product

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11
Q

etoposide

A

epipodophyllotoxin

-natural product

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12
Q

doxorubicin

A

antibiotic

-natural product

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13
Q

blemoycin

A

anthracenedione

-natural product

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14
Q

L-asparaginase

A

enzyme

-natural product

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15
Q

imatinib

A

protein kinase inhibitor

-misc agent

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16
Q

trastuzumab

A

monoclonal Ab

-misc agent

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17
Q

leucovorin

A

rescue agent

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18
Q

mesna

A

rescue agent

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19
Q

ondansetron

A

serotonin antagonist

-used to minimize adverse effects

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20
Q

curable by chemo

A 
ALL
AML
ewing
hodgkin
non-hodgkin
DLBCL
wilms
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21
Q

causes of cancer

A

radiation
carcinogens
Hep B and C, HIV, HPV, EBV

and genetic predisposition

22
Q

primary induction treatment

A

first treatment given

23
Q

neoadjuvant therapy

A

given before primary tx
-to shrink tumor

type of induction therapy

cancer for which alternative therapy exists but less effective

24
Q

adjuvant therapy

A

given after primary treatment

-lower risk cancer will come back

25
primary induction chemotherapy
as primary treatment - pt with no alternative - may be curative - hodgkin/NHL, AML, germ cell cancer
26
G1 phase
synthesis of components for DNA synthesis
27
S phase
DNA synthesis
28
G2 phase
synthesis of components for cell division
29
M phase
cell divides to two daughter G1 cells activity of CDK and P16,p53 involved in transition of cell cycle
30
cell cycle specific
cytotoxic during specific phase of cell cycle
31
cell cycle nonspecific
cytoxic regardless of whether cell is cycling or resting (G0)
32
CCS drugs
``` antimetabolites taxanes vinca alkaloids camtothecins epipodophyllotoxins antitumor antibiotics - blemoycin ```
33
CCNS drugs
``` alkylating agents anthracyclines antitumor antibiotics antimetabolites - cladribine platinum analogs ```
34
S phase CCS
antimetabolites and camptothecins
35
S-G2 phase CCS
epipodophyllotoxins | -etoposide
36
G2-M phase CCS
blemoycin
37
M phase CCS
taxanes | vinca alkaloids
38
growth fraction
ration of proliferating cells to cells in G0 phase
39
solid tumors
lower growth fraction than disseminated cancers
40
increase of growth fraction
can be induced by surgery or radiation | -make more susceptible to antineoplastic chemo agents
41
burkitt lymphoma
100% growth fraction | -curable with chemo
42
trophoblastic choriocarcinoma
100% growth fraction | -curable with chemo
43
lung and colon cancer
slow growing | -10% growth fraction
44
true cure
eradication of every cancer cell
45
indications for chemo
tumor not amenable to surgery | -also as supplemental treatment to prevent metastasis with surgery/radiation
46
log cell kill hypothesis
chemo kills fraction of drugs -first-order kinetics three-log cell kill - 10^12 to 10^9
47
pharmacologic sanctuaries
regions where tumors cells less susceptible to antineoplastic agnents interior of solid tumors or CNS, testes may require localized radiation or surgical resection
48
intermittent high dose therapy
most common allows recovery of normal tissue more effective with CCNS drugs
49
continuous infusion therapy
drugs metabolized/excreted more effective also CCS drugs more effective this way
50
routes of administration for chem
IV and PO
51
colorectal cancer
mets to liver - use intraarterial perfusion of chemo drugs to cathgeter in hepatic artery lt route of admin**
52
drug combo
benefits - 1 maximal cell killing within range of tolerated toxicity 2 effective against broader range of clones with different genetic abnormalities 3 may delay or prevent development of drug-resistant tumors

HEME/LYMPH Exam 2 (16 decks)

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