Lymph Node Pathology Flashcards
What cells are in the Paracortex of a lymph node
Naive T cells, high endothelial venules and interdigitating DCs
What cells are in the Primary Follicles of a lymph node
Naive B cells, Follicular DCs and T helper cells,
What cells are in the Mantle zone of a lymph node
Naive B cells
What is the process in which germinal centres undergo
Naive B cells after stimulation will undergo somatic hypermutation, then immunoglobulin class switching, then mature from centroblasts to centrocytes and then to immunoblasts
After leaving the follicle, where to immunoblasts migrate?
They move along the Medulla chords and mature to plasma cells which can then leave to secrete antibodies or they can become memory cells
What happens to centroblasts that undergo apoptosis
Didn’t produce a appropriate antibody and underwent apoptosis and consequently phagocytosed by macrophages
Why can lymph nodes be inflammed
Neoplasia (primary or secondary), infection (localised or systemic), autoimmune diseases or drugs
What translocation is commonly seen with follicualr lymphomas
t(14:18) leading to a IgH and Bcl-2 follicular lymphomas
What translocation is commonly seen with burkitt’s lymphomas
t(8:14) in which c-Myc oncogene is translocated onto IgH promoter
What are the histological appearence of Hodgekin’s Lymphomas
Reed-Sternberg cells with a background of non-neoplastic lymphocyes and other inflammatory cells
What are the 3 most common B cell NHLs
Diffuse large B cell lymphpoma (30%), FOllicular (20% and SLL and CLL (5-10%)
Histology of Diffuse large B cell lymphoma
Recapitulate germinal centre of post-germinal centre B cells (centroblasts and immunoblasts)
Histology of Follicular NHL
Differentiating B cells within a germinal centre and hence form nodules/follicles
What typical histological features can be seen in AML
Auer Rods
What types of leukeamias can a Starry Sky be seen
Burkitts and ALL
