Lymph Flashcards
Which cells are involved in lymphomas?
→mostly B lymphocytes
→ T lymphocytes
→natural killers
What are the main functions of the lymph nodes?
→blood filtration/purification
→removal of excess fluids from tissues
→absorption and transport of lipids
→Immune system activation
What are primary lymph organs?
→sites where stem cells can divide and become immunocompetent
→What are secondary lymph organs?
→sites where most of the immune responses occur
When lymphomas spread to the bone marrow, how are they detected?
→detectable in blood
What are the traditional classifications of lymphomas?
→Non-Hodgkin’s
→Hodgkins
What are the two types of Non-Hodgkin’s lymphomas?
→diffuse
→follicular
What is the age of onset of HK and NHK lymphomas?
→HK= 75-79 →NHK= 80-84
What are the warning signs of lymphomas?
→swelling of face and neck →excessive sweating at night →unexpected weight loss →breathlessness itchiness →loss of appetite
How are lymphomas diagnosed?
→lymph node biopsy →immunophenotyping →NGS →FISH →flow cytometry
What are the PET stages of lymphomas?
→Stage 1= localized disease, single lymph node
→Stage 2= two or more lymph nodes on the same of the diaphragm
→Stage 3= two or more nodes above and below diaphragm
→Stage 4= widespread disease, multiple organs
How do most lymphomas occur?
→when a B cell develops/acquires a mutation in its DNA
What is Hodgkin lymphoma?
→Clonal B-cell malignancy
What is the presentation of HK lymphomas?
→Presentation- non-painful enlarged lymph node(s)
What are the risk factors of HK lymphomas?
→50% cases due to Epstein-Barr virus
→Family history
→HIV/AIDS
How is HK lymphomas diagnosed?
→Excisional lymph node biopsy
→Reed-Sternberg cell present
→observed by light microscope
What are the features of Reed-Sternberg cells?
→multinucleated
→condensed cytoplasm
What is the treatment for HK lymphomas?
→Chemotherapy +/- radiotherapy
→Stem cell transplant
What is the prognosis for HK lymphomas?
→5 year survival ~50-90% depending on age, stage and histology
What are two high grade NHK lymphomas?
→diffuse large B cell
→Burkitt
What is the main presentation of HK lymphomas?
→enlarged lymph node