CD Flashcards

1
Q

What is an idiopathic disease?

A

Conditions with no known cause

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2
Q

What are examples of intrinsic causes?

A

→Nuclear or mitochondrial
→Inherited mutations and other genetic variations
→de novo mutations
→Epigenetic modifications

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3
Q

What are the levels genetic variations can manifest at?

A

→Cell autonomously

→Cell non-autonomously

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4
Q

What is the difference between cell autonomously and non-autonomously?

A

Cell autonomously= Cell X no longer expresses structural protein Y, so cell X is the wrong shape

Cell non-autonomously= Cell X no longer secretes protein hormone Y, so cell Z no longer functions

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5
Q

Give examples of extrinsic causes

A
→Injury
→Infection
→Nutrition and diet
→Lifestyle, e.g. smoking, exposure to workplace toxins
→Chemical poisoning (acute and chronic)
→Exposure to radiation
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6
Q

How can age be an intrinsic cause?

A

→when it describes the biological process of ageing

eg osteoporosis, chronic inflammation

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