CD Flashcards
What is an idiopathic disease?
Conditions with no known cause
What are examples of intrinsic causes?
→Nuclear or mitochondrial
→Inherited mutations and other genetic variations
→de novo mutations
→Epigenetic modifications
What are the levels genetic variations can manifest at?
→Cell autonomously
→Cell non-autonomously
What is the difference between cell autonomously and non-autonomously?
Cell autonomously= Cell X no longer expresses structural protein Y, so cell X is the wrong shape
Cell non-autonomously= Cell X no longer secretes protein hormone Y, so cell Z no longer functions
Give examples of extrinsic causes
→Injury →Infection →Nutrition and diet →Lifestyle, e.g. smoking, exposure to workplace toxins →Chemical poisoning (acute and chronic) →Exposure to radiation
How can age be an intrinsic cause?
→when it describes the biological process of ageing
eg osteoporosis, chronic inflammation