Lyme and Ehrlichia Flashcards

1
Q

What age groups are most often affected by Lyme disease?

A

bimodal distribution: children aged 5-14 and adults aged 55-70 years

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2
Q

What is the causative agent of Lyme disease

A

Borrelia burgdorferi, a spirochete

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3
Q

A wide array of ______ help B. burgdorferi adapt to mammalian and arthropod hosts

A

outer surface proteins

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4
Q

The only known virulence factor of B. burgdorferi are _____

A

lipoproteins

no known toxins

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5
Q

What tick is responsible for the transmission of Lyme disease?

A

Ixodes scapularis in NE and central US
can also transmit anaplasmosis (HGA) and babesiosis

Ixodes pacificus in Pacific US
can also transmit anaplasmosis (HGA)

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6
Q

Tick larvae emerge in the _____ and take a blood meal, usually from a bird or small mammal

A

spring/ early summer

if animal is infected, tick becomes infected

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7
Q

Humans are most likely to be infected with Lyme by a tick in the ____ stage of development

A

nymph

or adult, not larvae- have not yet taken a blood meal

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8
Q

Why are adult ticks less likely to transmit Lyme to a human?

A

More likely to be noticed and removed

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9
Q

List factors that determine the risk of infection in humans in a given region

A

Tick density
Tick feeding habits
Proportion of ticks infected
Animal host availability- important in maintaining B burgdorferi in the environment
Amount of time spent outdoors during tick season

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10
Q

How long is B burgdorferi incubation period?

A

7-14 days

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11
Q

Describe the early localized stage of Lyme disease

A

7-14 day incubation period then rash develops
Erythema migrans at the site of the tick bite, usually thigh, buttock, groin, axilla
Non-specific constitutional symptoms

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12
Q

Describe early disseminated stage of Lyme disease

A

Days to weeks after infection
Multiple secondary erythema migrans lesions
MSK- migratory joint pain, muscle pain
Neurologic- meningitis, facial nerve paralysis, radicular neuropathy
CV- new onset AV block
ocular involvement

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13
Q

Describe the late disseminated stage of Lyme disease

A

Months after infection
intermittent large joint arthritis
encephalopathy w/ cognitive and personality changes
spastic paresis, ataxia, fatigue

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14
Q

A single dose of doxycycline can be given as prophylaxis for tick bites if:

A
  • attached tick identified as nymph or adult Ixodes scapularis, has been present for >24 hours
  • prophylaxis within 72 hours of removal
  • local tick infection rate >20%
  • no contraindications to doxycycline
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15
Q

Describe the CSF profile of a person with Lyme meningitis

A

aseptic meningitis profile with lymphocytes in the CSF, normal glucose and elevated protein

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16
Q

List complications of Lyme disease

A

Lyme meningitis
Lyme carditis
Lyme arthritis
Post-Lyme disease syndrome

17
Q

What is the appropriate treatment for Lyme with nervous or cardiac involvement?

A

ceftriaxone

18
Q

Lyme arthritis may persist despite antibiotics, and is then thought to be ______ in nature

A

autoimmune

19
Q

How is Lyme disease diagnosed?

A

In early localized infection, it is a clinical diagnosis- antibodies will be negative
2 step testing is recommended- ELISA then Western blot

20
Q

Lyme serology cannot distinguish ____ from ____ infection

A

past from active

21
Q

What antibiotic is usually used to treat Lyme disease?

A

Doxycycline
Amoxicillin or cefuroxime if pregnant, lactation, children
Ceftriaxone for neurologic involvement, AV block, recurrent arthritis

22
Q

Distinguish human granulocytic anaplasmosis from human monocytotropic ehrlichiosis

A

Human granulocytic anaplasmosis (HGA)
- Caused by Anaplasma phagocytophilum; found in granulocytes
- Distribution and risks mimic Lyme disease because of the shared tick vector, Ixodes scapularis. In the west, it is spread
by Ixodes pacificus.
- Animal reservoir is white tailed deer

Human monocytotropic ehrlichiosis (HME)
- Caused by Ehrlichia chaffeensis; found in monocytes
- Distribution mostly S Central and SE US because of the distribution of the
primary tick vector, Amblyomma americanum (the Lone Star tick)
- Animal reservoir is white tailed deer

23
Q

Both anaplasmosis and erhlichiosis organisms are _______ bacteria with tropism for leukocytes

A

obligate intracellular

24
Q

What is a morulla?

A

Ehrlichia or anaplasmosis organisms grouped together within cytoplasmic vacuoles in infected cells

25
Q

Describe the clinical symptoms of Ehrlichia

A

fever, headache, myalgia, malaise
NV, arthralgia, cough, mental status change
rash: maculopapular > petechial
if severe: shock, hemorrhage, ARDS

26
Q

Describe the lab findings in Ehrlichia

A
low platelets 
low WBCs
anemia (slow decline)
high ALT/AST
high creatinine
27
Q

Describe the pathogenesis of ehrlichia

A

Tick bite–> organisms disseminate to the bone marrow and reticuloendothelial organs then attach to and infect granulocytes (HGA) or monocytes/ macrophages (HME)
Can find non-caseating, necrotizing granulomas in the bone marrow and reticuloendothelial organs
Host inflammatory response is the cause of much of the end organ pathology

28
Q

In general, there is less CNS disease and lower mortality in ____ and rash is more common in _____

A

HGA

HME

29
Q

What is appropriate treatment for ehrichia

A

Doxycycline 10-14 days, start BEFORE lab diagnosis is made

Improvement will be rapid once doxycycline is started