Lyme and Ehrlichia Flashcards
What age groups are most often affected by Lyme disease?
bimodal distribution: children aged 5-14 and adults aged 55-70 years
What is the causative agent of Lyme disease
Borrelia burgdorferi, a spirochete
A wide array of ______ help B. burgdorferi adapt to mammalian and arthropod hosts
outer surface proteins
The only known virulence factor of B. burgdorferi are _____
lipoproteins
no known toxins
What tick is responsible for the transmission of Lyme disease?
Ixodes scapularis in NE and central US
can also transmit anaplasmosis (HGA) and babesiosis
Ixodes pacificus in Pacific US
can also transmit anaplasmosis (HGA)
Tick larvae emerge in the _____ and take a blood meal, usually from a bird or small mammal
spring/ early summer
if animal is infected, tick becomes infected
Humans are most likely to be infected with Lyme by a tick in the ____ stage of development
nymph
or adult, not larvae- have not yet taken a blood meal
Why are adult ticks less likely to transmit Lyme to a human?
More likely to be noticed and removed
List factors that determine the risk of infection in humans in a given region
Tick density
Tick feeding habits
Proportion of ticks infected
Animal host availability- important in maintaining B burgdorferi in the environment
Amount of time spent outdoors during tick season
How long is B burgdorferi incubation period?
7-14 days
Describe the early localized stage of Lyme disease
7-14 day incubation period then rash develops
Erythema migrans at the site of the tick bite, usually thigh, buttock, groin, axilla
Non-specific constitutional symptoms
Describe early disseminated stage of Lyme disease
Days to weeks after infection
Multiple secondary erythema migrans lesions
MSK- migratory joint pain, muscle pain
Neurologic- meningitis, facial nerve paralysis, radicular neuropathy
CV- new onset AV block
ocular involvement
Describe the late disseminated stage of Lyme disease
Months after infection
intermittent large joint arthritis
encephalopathy w/ cognitive and personality changes
spastic paresis, ataxia, fatigue
A single dose of doxycycline can be given as prophylaxis for tick bites if:
- attached tick identified as nymph or adult Ixodes scapularis, has been present for >24 hours
- prophylaxis within 72 hours of removal
- local tick infection rate >20%
- no contraindications to doxycycline
Describe the CSF profile of a person with Lyme meningitis
aseptic meningitis profile with lymphocytes in the CSF, normal glucose and elevated protein