LuTx

Question 1

Indication for LuTx

Answer 1

50% risk of death due to lung disease within 2 years without the LuTx

Question 2

LuTx main causes

Answer 2

IPF
CF
COPD
Emphysema
iPAH
LymphAngioMyomatosis

Question 3

Absolute contraindications for LuTx

Answer 3

Active smoker
Failure of other organs
Cancer
HIV
Hep. C/B
Medical non-compliance
Sepsis
MRSA
No social support

Question 4

Donor and recipient match based on (3)

Answer 4

Size
Blood group
HLA

Question 5

Surveillance controll after LuTx-
What do you do in the first 3 months?
How often?

Answer 5

Every week

Lung func, Xray, ECG, CMV Ag, Chemistry

Question 6

When will you do bronchoscopy?

Answer 6

week 2,4,8

Month 3.6.12

Question 7

Every 6 month post LuTx, what will you preform?

Answer 7

Chest CT

Question 8

immunosuppresive therapy after LuTx

Answer 8

Calcineurin inhibitor
Antimetabolite
Steroids

Alsa
mTOR inhibitor

Question 9

Antimicrobial treatment after LuTx

Answer 9

Amphotericin B
TMP/SMX
Valgancyclovir

Question 10

Amphotericin B is against

Answer 10

Aspargillus Fumigatus

Question 11

TMP/SMX is against

Answer 11

Pneumocystis jirovecii

Question 12

Valgancyclovir is against

Answer 12

CMV

Question 13

Types of graft failure

Answer 13

Acute
Subacute
Chronic

Question 14

Chronic Graft is devided into

Answer 14

Bronchiolitis Obliterans Syndrome

Restrictive Allograft Syndrome

Question 15

Genetic background of CF disease

Answer 15

Autosomal Recessive

Question 16

What is the mutation in CF?

Answer 16

F508

Phenylalanine

Question 17

Lung manifestation in CF

Answer 17

Mucus dehydrated
Bronchiectasis
PTX
Haemoptysis
Cor pulmonale

Question 18

Sweat Cl- testing will show us what in CF patients?

Answer 18

NaCl is not absorbed properly so sweat is Hypertonic

Above 60 mEq/L