Lutheran Blood Group

Question 1

What is the most common Lutheran phenotype?

Answer 1

Lu(a-b+)

Question 2

How do the Lutheran antigens react to enzyme treatment?

Answer 2

They are resistant to enzymes

Question 3

What immunoglobulin class is anti-Lu(a)? anti-Lu(b)?

Answer 3

Lu(a) is IgM, Lu(b) is IgG

Question 4

At what temperature does anti-Lu(a) react best? Anti-Lu(b)?

Answer 4

Lu(a) room temperature, Lu(b) 37C or body temperature

Question 5

Can anti-Lu(a) cause HDFN or TRXNs? Anti-Lu(b)?

Answer 5

Anti-Lu(a) No, Lu(b) yes though mild

Question 6

What are the three different mechanisms to acquire the Lu(a-b-) phenotype?

Answer 6

Dominant type, recessive type, X-linked inhibitor

Question 7

Describe how the dominant type Lu(a-b-) phenotype is created.

Answer 7

The EKLF gene that is inherited codes for In(Lu) which is an inhibitor of the Lutheran genes.

Question 8

Describe how the recessive type Lu(a-b-) phenotype is created.

Answer 8

Two rare silent LuLu alleles are inherited at the Lu locus. This is the official null phenotype.

Question 9

Describe how the X-linked inhibitor Lu(a-b-) phenotype is created.

Answer 9

The individual inherits the gene XS2 on the X chromosome that inhibits Lutheran expression.

Question 10

Which Lu(a-b-) phenotype(s) will still show trace amounts of the Lutheran antigens?

Answer 10

Dominant type and X-linked inhibitor

Question 11

Which Lu(a-b-) phenotype(s) will have a weaker expression of P1, i, and AnWj?

Answer 11

Dominant type

Question 12

Which Lu(a-b-) phenotype(s) can make an anti-Lu3?

Answer 12

Recessive type