Cryoprecipitate, Granulocytes and Derivatives Flashcards
Exam 3
Which factors are found in cryoprecipitate?
Fibrinogen, factor VIII, factor XIII, vWF, fibronectin
Describe the process of preparing cryoprecipitate from whole blood.
Thaw a unit of FFP at 1-6C. Centrifuge plasma at 4C with a hard spin. Take the plasma off and retain the cryo that is left at the bottom. Refreeze the cryo within 1 hour.
List clinical indications that would suggest transfusing cryoprecipitate.
Fibrinogen replacement, liver failure, DIC, massive transfusion
What is the main use of cryoprecipitate transfusion?
Fibrinogen replacement
How much fibrinogen and factor VIII is required to be present in one unit of cryo concentrate?
150 mg of fibrinogen and 80 IU of Factor VIII
When transfusing cryoprecipitate should it be red cell ABO compatible or plasma ABO compatible? Why?
Compatibility is not important because cryoprecipitate is considered acellular.
List the clinical indications for a granulocyte transfusion?
Severe neutropenia due to infection, septicemia
What is the dosage for transfusing granulocytes?
1 unit daily for 4 or more days
When transfusing a granulocyte should it be red cell ABO compatible or plasma ABO compatible? Why?
Red cell ABO compatible because there is high number of RBCs present. For this reason the unit must also be crossmatched like a red cell would.
What is the minimum number of granulocytes that must be present in a granulocyte product?
1 x 10^10
How are granulocytes collected?
Apheresis
What is Rhogam?
Concentrated IgG anti-D that prevents pregnant women from becoming sensitized to the Rh D antigen.
What factor concentrate is used for the treatment of Hemophilia A?
Factor VIII Concentrate and Activated Factor VII concentrate
What factor concentrate is used for the treatment of Hemophilia B?
Factor IX concentrate
What is the plasma derivative albumin used for?
Hypovolemia, hypoproteinemia, shock and burn patients
