FFP Products Flashcards
Exam 3
Describe the preparation of plasma from whole blood.
Centrifuge for a short light spin (2-3 min @ 3200 rpm). Separate the plasma from the RBCs. Centrifuge the plasma with a heavy spin (5 min @ 3600 rpm) separating the plasma from the platelets. Take off the plasma and freeze.
What is the definition of Fresh Frozen Plasma (FFP)?
Plasma that has been separated and frozen within 8 hours of collection
What is the definition of FFP, Thawed? Which clotting factors are present in FFP?
Frozen FFP that has been thawed and is used within 24 hours (this has all the labile and stable clotting factors)
What is the definition of Thawed Plasma? Which clotting factors are present in thawed plasma?
Frozen FFP that has been thawed for >24 hours. This can be used up to 5 days from the date of thaw and contains only the stable clotting factors.
What is the definition of Plasma Cryoprecipitate Reduced or Cryopoor Plasma?
The frozen plasma is thawed at 1-6C and the precipitate (cryo) is removed. The rest of the plasma is refrozen. This plasma therefore has had the factors VIII, XIII, fibrinogen, vWF, cryoglobulin, and fibronectin removed.
What is the definition of Plasma Frozen within 24 hours of collection (FP24)?
The plasma has been frozen within 24 hours of collection instead of the usual 8 hours of collection. This has slightly reduced levels of factor VIII.
What are the PT and APTT levels that indicate a plasma transfusion may be necessary?
PT: it if is 1.5x the midrange of normal or an INR >2.0, APTT: if it is 1.5x the top of normal range
What clinical diseases or situations could require a plasma transfusion?
Liver disease, DIC, vitamin K deficiency, Warfarin overdose, massive transfusion, multi-factor deficiencies, TTP
If a patient is type O, what type plasma products can they receive?
Any type
If a patient is type B, what type plasma products can they receive?
B or AB
Is the Rh of the donor and patient important when transfusing plasma products? Why?
No, there are not enough residual red cells in the plasma product to immunize a patient to the D antigen and plasma donors must be negative for RBC antibodies (including anti-D).
What is a plasma exchange?
Removing plasma from the patient and returning the platelets and red cells back to the patient. The plasma is replaced with either albumin, donor plasma, or both.
What are some common clinical indications for a plasma exchange?
TTP, Waldenstrom’s macroglobulinemia, Guillian-Barre syndrome, transplant rejection, myasthenia gravis
