Lupus - clinical presentation

Question 1

What is SLE?

Answer 1

A long term chronic systemic autoimmune condition

Question 2

Epidemiology of SLE?

Answer 2

1. 20 - 40 years female

2. highest in african american/hispanic

Question 3

Etiology of SLE?

Answer 3

1. HLA - DR2 and HLA - DR3 genetic predesposition

Question 4

Pathophysiology of SLE?

Answer 4

1. Type III hypersensitivity - antibody/antigen complex deposits on skin, kidneys, joints
2. Type II hypersensitivity -IgG and igM against antigens in cells

Question 5

What is the most common clinical presentation of SLE?

Answer 5

Skin > 70% of cases is affected

1. Malar rash (butterfly rash)
2. Photosensitivity
3. Joint involvement

Question 6

Dermatological : PC of SLE

Answer 6

1. Malar rash / butterfly rash sparing nasolabial folds
2. Discoid rash - erythematous raised patches
3. Photosensitivity
4. Oral ulcers

Question 7

Renal : PC of SLE

Answer 7

Lupus nephritis - proteinuria etv

Question 8

Neurological : PC of SLE

Answer 8

1. Seizures

2. Psychosis

Question 9

General systemic : PC of SLE

Answer 9

1. Fatigue
2. Joint swelling
3. Lymphadenopathy