Lung Neoplasm

Question 1

4 major cell types of Lung Ca

Answer 1

Small Cell
Non-small cell
Squamous cell
Large cell

Question 2

Distinguishes SCLC from NSCLC

Answer 2

Presence of neuroendocrine markers

CD56, NCAM, synaptophysin, chromgranin

Question 3

MC histologic type of NSCLC

Answer 3

Adenocarcinoma

Question 4

Most commonly associated with heavy tobacco use

Answer 4

Squamous and small-cell carcinomas

Question 5

Favorable subtype of invasive non-mucinous lung adenocarcinoma

Answer 5

Lepidic

poor: solid predominant, micropapillary

Question 6

Lack EGFR mutations, have strong KRAS mutation

Answer 6

Invasive mucinous lung adenocarcinoma

Question 7

Local extension of a tumor growing in the apex of the lung + 8th cervical, 1st and 2nd throcic nerve involvement + shoulder pain radiating in the ulnar distribution of the arm + radiologic destruction of the 1st and 2nd rib

Answer 7

Pancoast Tumor

usually coexist with Horner’s syndrome