GI

Question 1

MC esophageal Ca worldwide

Answer 1

Squamous

Question 2

Distributed commonly in the distal 1/3 of the esophagus

Answer 2

Adenocarcinoma

Question 3

Common initial symptoms of esophageal Ca

Answer 3

Progressive dysphagia

Weight loss of short duration

Question 4

Onset of symptom Indicates 60% Ca infiltration of the esophagus

Answer 4

Dysphagia

Question 5

Electrolyte abnormality in squamous cell Ca

Answer 5

Hypercalcemia

Question 6

MC type of Gastric Ca

Answer 6

Adenocarcinoma

Question 7

Gastric AdenoCa with poor prognosis

Answer 7

Diffuse Type

Question 8

Gastric AdenoCa often associated with H.pylori

Answer 8

Intestinal type

Question 9

Extreme hypertrophy of the gastric rugal folds which increases risk for malignant transformation

Answer 9

Menetrier’s disease

Question 10

MC site of hematogenous gastric tumor spread

Answer 10

Liver

Question 11

Only curative therapy of gastric Ca

Answer 11

complete surgical thmor removal with resection of adjacent lymph nodes

Question 12

Role of radiotherapy in gastric ca

Answer 12

Palliation

gastric tumors are radioresistant

Question 13

MC extranodal site for lymphoma

Answer 13

Stomach

pathology NHL of Bcell origin

Question 14

GIST therapy

Answer 14

Imatinib (Gleevec)

not responsive to conventional chemo

Question 15

Precursor for Colorectal Ca

Answer 15

Adenomatous polyps

Question 16

Most frequent type of colorectal Ca

Answer 16

Sessile type

Question 17

Histologic type with 3x malignant risk for colorectal ca

Answer 17

Villous adenomas

Question 18

Point mutation in colorectal carcinogenesis

Answer 18

k-ras gene

Question 19

2 subsets of Polyposis Coli

Answer 19

Gardner’s and Turcot’s syndrome

Question 20

“Apple-core” or “napkin-ring” constriction in radiography

Answer 20

Colorectal esp in the transverse and descending colon

Question 21

Most frequent visceral site of colorectal metastasis

Answer 21

Liver

Question 22

Optimal treatment of colorectal cA

Answer 22

Total resection of tumor

Question 23

Sensitive marker for tumor recurrence

Answer 23

CEA q 3 months

Question 24

Recommended surgery for rectal Ca

Answer 24

Total Mesorectal Excision

Question 25

Backbone of treatment for colorectal Ca

Answer 25

5FU

Question 26

Major side effect of FOLFIRI

Answer 26

Diarrhea

Question 27

Standard Adjuvant therapy for Colorectal Ca

Answer 27

FOLFOX

Question 28

More frequent ulcerations in anay Ca

Answer 28

Distal to the pectinate line | squamous cell histology

Question 29

Risk for anal Ca

Answer 29

HPV

Question 30

Most potent natural chemical carcinogen

Answer 30

Aflatoxin B

Question 31

Strongly associated with increased incidence of HCC

Answer 31

Chronic Hep B CARRIER state

Question 32

MC symptom of HCC

Answer 32

Abdominal pain

Question 33

MC sign of HCC

Answer 33

hepatomegaly

Question 34

HCC invasion of hepatic veins

Answer 34

Budd-Chiari syndrome | tense ascites and large tender liver

Question 35

HCC with best prognosis

Answer 35

Stage 1 | Solitary tumor <2cm without vascular invasion

Question 36

Serum tumor marker in HCC

Answer 36

AFP | more specific: AFP-L3

Question 37

May predict portal vein invasion

Answer 37

DCP (des-y-carboxy prothrombin)

Question 38

Screening for HCC

Answer 38

Liver UTZ

Question 39

Detect tumor size and extent and the presence of portal vein invasion accurately

Answer 39

Helical/triphasic CT of abdomen and pelvis

Question 40

Provides histologuc proof of the presence of HCC

Answer 40

Core liver biopsy

Question 41

Excluded from transplatation for HCC

Answer 41

If with portal vein involvement

Question 42

Reliable prognosticator for tolerance of hepatic surgery

Answer 42

Child Pugh Classification | Child A amenable for surgical resection

Question 43

Mucin-producing adenocarcinoma that arise from the bile ducts

Answer 43

Cholangiocarcinoma

Question 44

Predisposing risk factor

Answer 44

Primary sclerosing cholangitis

Question 45

Typical presentation of cholangiocarcinoma

Answer 45

Painless jaundice

Question 46

Nodular tumors arising at the bifurcation of the CBD in CCC

Answer 46

Klatskin tumors | often assoc with a collapsed GB

Question 47

Majority of carcinoma of the Ampulla of Vater

Answer 47

Adenocarcinoma

Question 48

Most frequent metastasis of Ca of the Ampulla

Answer 48

Liver

Question 49

MC presentation of Ca of the Ampulla

Answer 49

Jaundice

Question 50

Most frequent site of pancreatic ca

Answer 50

Head of the pancreas

Question 51

MC environmental risk factor of pancreatic Ca

Answer 51

Cigarette smoking

Question 52

Pancreatic Ca precursor lesion

Answer 52

pancreatic intra epithelial neoplasia (PanIN)

Question 53

Clinical presentation of Ca arising from the pancreatic head

Answer 53

Obstructive Jaundice

Question 54

Palpable gallbladder

Answer 54

Courvoisier’s sign

Question 55

Left supraclavicukar lymphadenopathy

Answer 55

Virchow’s node

Question 56

Periumbilical nodules

Answer 56

Sister Mary Joseph’s nodes