Lung Cancer Flashcards
General names for different cancers are…
Carcinoma= organs Sarcoma= connective tissue & bones Melanoma=Skin Lymphoma= lymph nodes and infection fighting centres Leukaemia=blood
Cancer can be subdivided into 3 types which are…
1y Benign 1y Malignant (local invasion- pre metastatic) 2y (metastatic)
True/False:
Bronchial carcinoma is the 4th biggest killer in the UK
False
3rd
What are the 2 biggest subgroups of bronchial carcinomas…
Small Cell & Non Small Cell Carcinoma
What cancers does Non Small Cell carcinoma include?
adenocarcinoma, squamous cell carcinoma, large cell carcinoma, large cell neuroendocrine
Where does metastasised 2y lung cancer to lung usually stem from?
Mediastinal glands
What is bronchial carcinoma?
Neoplasms in the lung
True/False:
Benign tumour often caused by smoking
False:
MALIGNANT tumour often caused by smoking
Pathophysiology of bronchial carcinoma…
Toxins inhaled in smoke cause mutations to cells and DNA resulting in cancer
Main aetiology of bronchial carcinoma…
Environmental: smoking, radon exposure, asbestos (mesothelioma)
Host factors: genetic, HIV, pre-existing lung disease
Presenting symptoms of 1y tumour…
3 week cough, haemoptysis, wt loss, finger clubbing, bloated face, dull percussion, HPOA, lethargy, recurrent infections, hypercalcaemia, thrombophlebitis
Malignant: Chest pain, hoarse voice, stridor, SOB, pleural effusion
Where can local invasion of 1y bronchial carcinoma occur?
laryngeal nerve, pericardium, oesophagus, sup VC
BC Ix…
- Imaging: CXR, CT, PET, Bronchoscopy & Endobronchial USS
- FBC, spirometry, immunohistochemical staining
- Exam
BC Tx…
surgery, radio therapy, chemo therapy, palliative, molecular pathology
Tx for NSCLC…
surgery (pneumonectomy/lobectomy), radio