Lung Cancer

Question 1

What is Cetuximab?

Answer 1

a monoclonal antibody

Question 2

A ______ tells us the outcome based on the natural course of the disease without any therapeutic intervention.

Answer 2

prognostic biomarker

Question 2

What is Gefitinib?

Answer 2

an EGFR inhibitor

Question 2

What test detects a gene mutation in lung cancer?

Answer 2

Sanger Sequencing or NexGen Sequencing

Question 2

An ALK gene rearrangement occurs in ____ of patients.

Answer 2

3%

Question 4

What is targeted therapy?

Answer 4

giving drugs based on specific molecular characteristics

Question 4

Name 2 ALK inhibitors.

Answer 4

1) Crizotinib 2) Ceritinib

Question 5

What is Ceritinib?

Answer 5

an ALK inhibitor

Question 6

Predictive markers relate the outcome based on _____.

Answer 6

a specific therapy

Question 6

What is Necitumumab?

Answer 6

a monoclonal antibody

Question 7

Name 2 monoclonal antibody drugs for lung cancer.

Answer 7

1) CETUXIMAB 2) NECITUMUMAB

Question 9

Name 3 subtypes of NSCLCs.

Answer 9

1) adenocarcinoma 2) squamous cell carcinoma 3) large cell carcinoma

Question 10

Name 2 general types of EGFR inhibitors.

Answer 10

1) tyrosine kinase inhibitors 2) antibodies

Question 10

A prognostic biomarker tells us the outcome based on the ______.

Answer 10

natural course of the disease without any therapeutic intervention

Question 10

Where is the ALK gene located?

Answer 10

chromosome 2

Question 12

What is the problem with the National Lung Cancer Screening Trial?

Answer 12

95% false positive rate

Question 13

What assays detect the ALK gene fusion?

Answer 13

FISH, protein expression, PCR

Question 15

What does SCLC stand for?

Answer 15

small cell lung cancer

Question 16

_____ make up 85% of all lung cancers.

Answer 16

NSCLCs

Question 18

What is the treatment for NSCLCs?

Answer 18

personalized treatments- targeted therapy

Question 18

Name 3 EGFR inhibitor drugs for lung cancer.

Answer 18

1) Erlotinib 2) Gefitinib 3) Afatinib

Question 20

______ is overexpressed in lung cancer.

Answer 20

EGFR/HER2

Question 21

____ relate the outcome based on a specific therapy.

Answer 21

Predictive markers

Question 22

What is Afatinib?

Answer 22

an EGFR inhibitor

Question 24

What are the positive results seen with the National Lung Cancer Screening Trial?

Answer 24

1) 20% mortality reduction in lung cancer 2) 6.7% all cause mortality reduction

Question 25

_____ make up 15% of all cancers and have a 5-year survival rate of 6%.

Answer 25

SCLCs

Question 26

What is Erlotinib?

Answer 26

an EGFR inhibitor

Question 27

What is the molecular problem in the EGFR in lung cancer?

Answer 27

a mutation

Question 28

What does NSCLC stand for?

Answer 28

non-small cell lung cancer

Question 30

What is the treatment for SCLC?

Answer 30

chemotherapy

Question 31

What is Crizotinib?

Answer 31

an ALK inhibitor

Question 32

What is the 5 year survival rate of lung cancer?

Answer 32

16%

Question 33

What is the most aggressive lung cancer type?

Answer 33

SCLCs

Question 34

What does EGFR stand for?

Answer 34

epidermal growth factor receptor

Question 35

Where is the EGFR gene located?

Answer 35

chromosome 7

Question 36

What percent of lung cancer pts die?

Answer 36

29%

Question 37

What is the molecular problem in the Anaplastic Lymphoma Kinase (ALK) in lung cancer?

Answer 37

a gene rearrangement