Lung Cancer Flashcards
What is Cetuximab?
a monoclonal antibody
A ______ tells us the outcome based on the natural course of the disease without any therapeutic intervention.
prognostic biomarker
What is Gefitinib?
an EGFR inhibitor
What test detects a gene mutation in lung cancer?
Sanger Sequencing or NexGen Sequencing
An ALK gene rearrangement occurs in ____ of patients.
3%
What is targeted therapy?
giving drugs based on specific molecular characteristics
Name 2 ALK inhibitors.
1) Crizotinib 2) Ceritinib
What is Ceritinib?
an ALK inhibitor
Predictive markers relate the outcome based on _____.
a specific therapy
What is Necitumumab?
a monoclonal antibody
Name 2 monoclonal antibody drugs for lung cancer.
1) CETUXIMAB 2) NECITUMUMAB
Name 3 subtypes of NSCLCs.
1) adenocarcinoma 2) squamous cell carcinoma 3) large cell carcinoma
Name 2 general types of EGFR inhibitors.
1) tyrosine kinase inhibitors 2) antibodies
A prognostic biomarker tells us the outcome based on the ______.
natural course of the disease without any therapeutic intervention
Where is the ALK gene located?
chromosome 2
What is the problem with the National Lung Cancer Screening Trial?
95% false positive rate
What assays detect the ALK gene fusion?
FISH, protein expression, PCR
What does SCLC stand for?
small cell lung cancer
_____ make up 85% of all lung cancers.
NSCLCs
What is the treatment for NSCLCs?
personalized treatments- targeted therapy
Name 3 EGFR inhibitor drugs for lung cancer.
1) Erlotinib 2) Gefitinib 3) Afatinib
______ is overexpressed in lung cancer.
EGFR/HER2
____ relate the outcome based on a specific therapy.
Predictive markers
What is Afatinib?
an EGFR inhibitor
What are the positive results seen with the National Lung Cancer Screening Trial?
1) 20% mortality reduction in lung cancer 2) 6.7% all cause mortality reduction
_____ make up 15% of all cancers and have a 5-year survival rate of 6%.
SCLCs
What is Erlotinib?
an EGFR inhibitor
What is the molecular problem in the EGFR in lung cancer?
a mutation
What does NSCLC stand for?
non-small cell lung cancer
What is the treatment for SCLC?
chemotherapy
What is Crizotinib?
an ALK inhibitor
What is the 5 year survival rate of lung cancer?
16%
What is the most aggressive lung cancer type?
SCLCs
What does EGFR stand for?
epidermal growth factor receptor
Where is the EGFR gene located?
chromosome 7
What percent of lung cancer pts die?
29%
What is the molecular problem in the Anaplastic Lymphoma Kinase (ALK) in lung cancer?
a gene rearrangement
