LU, CO, XG

Question 1

ISBT

Answer 1

005

Question 2

FIRSTS

Answer 2

First autosomal linkage with Se in man

First autosomal crossing over in man

Question 3

Antithetical pairs

Answer 3

Lua/Lub
Lu6/Lu9
Lu8/Lu14
Lu18/Lu19

Question 4

Low incidence

Answer 4

Lu9, Lu14

Question 5

Antigens

Answer 5

Weak on cord cells
Not in plasma
Fragile
Present on other tissues

Question 6

Antigens on red cells

Answer 6

Variable # among different individuals: variable strength on different test cells
Variable # antigens in same person: MF agglutination

Question 7

Anti-Lua

Answer 7

Mostly benign
More active at lower temperature
HTR extremely rare
HDFN none to mild

Question 8

Anti-Lub

Answer 8

More significant
Mostly IgG1
Mild HDFN and HTR

Question 9

Anti-Lu3

Answer 9

Not reported to cause HDFN

Question 10

LuLu recessive

Answer 10

Mutations in LU gene
Can make anti-Lu
Very rare
Cells normal

Question 11

In(Lu)

Answer 11

Dominant supressor
Mutations in KLF1 gene
Have trace Lu antigen, cannot make anti-Lu
0.03% frequency
Weakens other antigens: P1, i, CD44, AnWj, Knops

Question 12

Lumod

Answer 12

X linked inhibitor
Have trace Lu antigen
Found in males of Australian family
Weak P1, enhanced i

Question 13

Gene

Answer 13

LU: Chromosome 19

Question 14

Gene product

Answer 14

BCAM. IgSF adhesion

Question 15

LU disease association

Answer 15

May be associated with PV

Question 16

CO high prevalence

Answer 16

Coa

Question 17

CO cord cells

Answer 17

Expressed

Question 18

CO enzyme DTT

Answer 18

Resistant to both

Question 19

CO:-3

Answer 19

No AQP1

Question 20

CO:-4

Answer 20

Normal AQP1, cells are CO:3

Question 21

CO antibodies

Answer 21

Rare, not immunogenic

Implicated in HTR and HDFN

Question 22

XG gene product

Answer 22

Single pass, linked to STS

Question 23

X linked

Answer 23

X linked dominant in female

Question 24

XG genetics

Answer 24

Xga+ male and an Xga- female will produce all Xga- males and Xga+ females

Question 25

XG enzymes/DTT

Answer 25

Resistant to both

Question 26

XG antibodies

Answer 26

Not immunogenic

Question 27

Klinefelters

Answer 27

Paternal XY entering same cell

Question 28

Turners

Answer 28

Father passed X, no maternal X passed

Question 29

Escapes lyonization

Answer 29

Heterozygous female with Xga+ and Xga- shows all red cells are Xga+
Lyon theory: in females one X will become inactivated