ABO Flashcards
1
Q
What are the ABO genes dependent on?
A
H gene chromosome 19 FUT1
ABO gene chromosome 9
2
Q
First known linkage in man?
A
ABO and nail patella syndrome
3
Q
What is the ancestral gene?
A
group A
4
Q
H antigen strength
A
O > A2 > B > A2B > A1 > A1B
5
Q
Bombay phenotype
A
Non secretor, no H gene
Makes potent anti-H and anti-A.B
Negative with anti-H lectin
Plasma only compatible with Bombay
6
Q
CIS AB
A
1 gene can make both A and B enzymes
2 nucleotide substitutions from A1
7
Q
True Bombay
A
Saliva lacks H
8
Q
Para Bombay
A
Only red cells lack H
A and B antigens may be weak (absorbed from type 1)
9
Q
ABO disease association
A
Group O have 25% less FVIII and vWF
Leukemia: suppressed A antigen
Myeloblastic leukemia: decreased H antigen
