LP #100 Immune Response & Terminology Ass. With Immunity Flashcards
1
Q
- Elicit an immune response
- Normally foreign to body
- free or bound
A
Antigens (Ag)
2
Q
- A.k.a immunoglobulins (Ig)
- All share similar Y-structures:
- It’s prongs are unique, where Ag binds
- Main stem: common to most Ig
A
Antibodies (Ab)
3
Q
- Ag + Ab =__________
- large & insoluble
- removed from circulation to tissue
A
Ag-Ab Aggregate
4
Q
- substances in body that elicit an abnormal response
* autoimmune disease
A
Antigenic
5
Q
- Humoral immunity is mediated by circulating AB’s produced by B-cells
- Destroy bacteria
- Neutralize bacterial toxins
- recognize free Ag (Ag in its natural state)
- Cause immediate allergic responses
- specificity d/t protein markers in plasma membrane
- Ability to destroy Ag d/t:
- recognition of specific Ag
- ability to produce specific Ab
A
B-Lymphocytes
6
Q
- Found in body secretions; saliva, sweat, intestinal juice & breast milk
- Helps prevent attachment of pathogens to epithelial cell surfaces (including mucus membranes & the epidermis)
- Exists in limited amounts in plasma
A
Immunoglobulin A (IgA)
7
Q
- Attached to the external surface of a B-lymphocytes (B-cells)
- Functions as the Ag receptors of B-cells
- Important in B-cell activation
A
Immunoglobulin D (IgD)
8
Q
- Very large antibody
- Attached to the external surface of a B-lymphocyte (B-cell)
- Functions as the Ag receptors of B-cells
- first Ig class released by plasma cells in the primary response (immunity)
- Activates complement
A
Immunoglobulin M (IgM)
9
Q
- Bound to mast cells & basophils-when triggered by an Ag, IgE causes these cells to release histamine & other mediators of inflammation
- Secreted by cell sin skin, Gi tract, respiratory tract & tonsils
- Active in allergies reactions
A
Immunoglobulin E (IgE)
10
Q
- Peaks~10 days from initial exposure
* Produces relatively few Ab molecules
A
1* immune response
11
Q
- Quickly multiplies
- Produces plasma cells & memory cells
- Peaks~ 2-3 days after exposure
- Produces more Ab’s
- Faster, stronger & longer than 1* response
A
2* immune response
12
Q
- cellular immunity is mediated by ______
- effective against foreign cells
- produce & secrete cytokines
- recognize membrane-bound Ag
- long living: circulate in blood & lymph
A
T-Lymphocytes
13
Q
T-cells main functions
A
- control coral infections
* allergies
14
Q
2 main populations of t-cells are
A
- CD4 (helper t-cells)
* Cd8 (cycotoxic/killer t-cells)
15
Q
- central role in adaptive immunity; master regulators for the immune system
- Helps activate B-cells & t-cells (induce proliferation)
- Release of their chemicals recruits other WBCs
- Activated helper t-cells can differentiate into distinct subpopulations of help t-cells
A
Helper T-cells
