low grade tumors

Question 1

What is DNETs?

Answer 1

• Typically in children or young adults.
• Grade 1 slow growing glioneuronal tumors.
• Either cortical or grey matter.
• Arise from secondary germinal layer
• up to 80% associated with cortical dysplasia.
• Characteristically cause intractable focal seizures (90%).
• 65% temporal lobe
• Heterogenous, often gelatinous w nodules of firmer tissue.
• T2 bubbly appearance.
• FLAIR bright rim sign

Question 2

How are DNETs distinguished from low-grade astrocytomas?

Answer 2

(? Jag vet inte om detta stämmer för barn, men de heter ju inte heller längre low grade astrocytomas?)
De har inte 1pq19 co-deletion.
De är IDH wt.
De har inte P53 mut.