Intracranial germ cell tumors Flashcards
What are the groups of intracranial germ cell tumors according to WHO (radiopedia)
- Germinoma - 60-70%
- Embryonal carcinoma
- yolk sac tumor
- choriocarcinoma
- teratoma - immature, - mature, - with malignant transformation
- mixed germ cell
What are the 6 groups of intracranial germ cell tumors according to WHO (radiopedia)
- Germinoma - 60-70%
- Embryonal carcinoma
- yolk sac tumor
- choriocarcinoma
- teratoma - immature, - mature, - with malignant transformation
- mixed germ cell
How many % of brain tumors are constituted by intracranial germ cell tumors?
about 1%
The male:female ratio is interresting in the non-germinatous tumors of the pineal. how does it look?
M:F = 9:1
What are the 6 types of intracranial germ cell tumors according to CNS WHO 5?
- germinoma (account for 60-80% of all cases)
- embryonal carcinoma
- yolk sac tumor
- choriocarcinoma
- teratoma
-immature
-mature
-teratoma with malignant transformation - mixed germ cell
As germinomas account for 60-80% of all germ cell tumors intracranially, a dichotomized expression for germ cell tumors are commonly used. Which?
- germinomas
- non-germinatous germ cells
where are germ cell tumors usually located?
They are midline clustered with a predilection of the PINEAL (2x all other sites) and suprasellar regions.
If a germ cell tumor is found in BG or Thalamus, it is usually one special of the 6 types. WHich one?
Germinoma.
Is it easy ton diverse germ cell tumors of different kinds and other pineal tumors?
No. But germinomas tend to be homogenously enhancing by gadolinium c. Hemorrhage is common in non-germinomatous germ cell tumors.
Compare prognosis of germinomas and non-germinomatous tumors.
- germnomas are exquisitely radiosensitive and cure ashived with radiation alone in 80-90% of pt.
- Non-germonomatous tumors have survvival rate of 40-70%
