Local Anes Flashcards
A condition that results when sensory transmission from a local area of the body to the CNS is blocked
Local anesthetics
Local anesthetics that areLong acting amides
Bupivacaine, ropivacaine
Local anesthetics that is an amide and has a medium action
Lidocaine
An ester local anesthetics that has a long action
Tetracaine
An ester local anesthetics that has a short action
Procaine
Ester local anesthetics that acts on surface action
Benzocaine and cocaine
Does shorter acting local anesthetics dependent on a vasoconstrictor to make their duration longer?
Yes
Does long acting agents dependent on vasoconstrictors?
No. They are less dependent
Where are amides metabolized?
Liver, by cytochrome P450 isoenzyme
What is the half life of lidocaine and prilocaine
1.5h
What are the longest acting amide local anesthetics
Bupivacaine and ropivacaine with a 3.5 and 4.2 HL
MOA of local anesthetics
Blocks the voltage dependent sodium channels and reduce the influx of sodium ions
Local anesthetics are commonly combined with?
A vasoconstrictor (epinephrine)
CNs toxic effects
Light-headedness or sedation, restlessness, nystagmus and tonic clonic convulsions
Severe convulsion may be followed by come with respiratory and CV depression
SE of abuse use of cocaine
Severe hypertension, cerebral hemorrhage, cardiac arrhythmias and MI
