Drugs With Significant Teratogenic Or Other Adverse Effects On The Fetus

Question 1

ACE inhibitors

Trimester -

Effect -

Answer 1

All, especially second and third

Renal damage, hypocalvaria

Question 2

Aminopterin

Trimester -

Effect -

Answer 2

First

Multiple gross anomalies

Question 3

Amphetamines

Trimester -

Effect -

Answer 3

All

Suspected abnormal developmental patterns, decreased school performance

Question 4

Androgens

Trimester -

Effect -

Answer 4

Second and third
Masculinization of female fetus

Question 5

Antidepressants, tricyclic

Trimester -

Effect -

Answer 5

Third

Neonatal withdrawal symptoms

Question 6

Barbiturates

Trimester -

Effect -

Answer 6

All
Chronic use can lead to neonatal dependence

Question 7

Busulfan

Trimester -

Effect -

Answer 7

All
Various congenital malformations; low birth weight

Question 8

Carbamazepine

Trimester -

Effect -

Answer 8

First
Neural tube defects

Question 9

Chlorpropamide

Trimester -

Effect -

Answer 9

All
Prolonged symptomatic neonatal hypoglycemia

Question 10

Clomipramine

Trimester -

Effect -

Answer 10

Third
Neonatal lethargy, hypotonia, cyanosis, hypothermia

Question 11

Cocaine

Trimester -

Effect -

Answer 11

All
Increase risk of spontaneous abortion; neonatal cerebral infarction, decreased school performance

Question 12

Diazepam

Trimester -

Effect -

Answer 12

All
Chronic use may lead to neonatal dependance

Question 13

Diethylstilestrol

Trimester -

Effect -

Answer 13

All
Vaginal adenosis, clear cell vaginal adenocarcinoma

Question 14

Ethanol

Trimester -

Effect -

Answer 14

All
Risk of fetal alcohol spectrum disorder

Question 15

Heroin

Trimester -

Effect -

Answer 15

All
Chronic use leads to neonatal abstrinence syndrome

Question 16

Iodine

Trimester -

Effect -

Answer 16

All
Congenital goiter, hypothyroidism

Question 17

Lithium

Trimester -

Effect -

Answer 17

First, third
Ebstein’s anomaly, neonatal toxicity after third trimester exposure

Question 18

Methadone

Trimester -

Effect -

Answer 18

All
Chronic use may lead to neonatal abstinence syndrome

Question 19

Methotrexate

Trimester -

Effect -

Answer 19

First
Multiple congenital malformations

Question 20

Misoprostol

Trimester -

Effect -

Answer 20

First
Möbius sequence

Question 21

Organic solvents

Trimester -

Effect -

Answer 21

First
Multiple malformations

Question 22

Penicillamine

Trimester -

Effect -

Answer 22

First
Cutix laxa

Question 23

Phencyclidine

Trimester -

Effect -

Answer 23

All
Poor suck reflex and feeding

Question 24

Phenytoin

Trimester -

Effect -

Answer 24

All
Fetal hydantoin syndrome

Question 25

Serotonin reuptake inhibitors

Trimester -

Effect -

Answer 25

Third
Neonatal abstinence syndrome, persistent pulmonary hypertension

Question 26

Smoking

Trimester -

Effect -

Answer 26

All
Intrauterine growth restriction; prematurity; sudden infant death syndrome; perinatal complications

Question 27

Tamoxifen

Trimester -

Effect -

Answer 27

All
Increased risk of spontaneous abortion or fetal damage

Question 28

Tetracycline

Trimester -

Effect -

Answer 28

All
Discoloration and defects of teeth and altered bon growth

Question 29

Thalidomide

Trimester -

Effect -

Answer 29

First
Phocomelia and many internal malformations

Question 30

Trimethadione

Trimester -

Effect -

Answer 30

All
Multiple congenital anomalies

Question 31

Warfarin

Trimester -

Effect -

Answer 31

First - hypoplastic nasalbridgge, chondrodysplasia punctata
Second - CNS malformations
Third - risk of bleeding