Histamine And Serotonin Drugs Summary

Question 1

First gen H1 antihistamine

Answer 1

Diphenhydramine

Question 2

Other first gen H1 blocker that has a less sedating H1 blocker with fewer autonomic effects

Answer 2

Chlorpheniramine

Question 3

Other H1 antihistamine blockers that has a strong sedating H1 blocker

Answer 3

Doxylamine

Question 4

This effect of drug reduces or prevents histamine effects on smooth muscle, immune cells. Also blocks muscarinic and a adrenoceptors

Highly sedative

Answer 4

Diphenhydramine

Question 5

An anti motion sickness drug

Answer 5

Diphenhydramine

Question 6

SE of this drug: orthostatic hypotension, hay fever, muscarinic blockage

Answer 6

Diphenhydramine

Question 7

IgE immediate allergies are used in?

Answer 7

Antihistamines

Question 8

An effect of this drug reduces or prevent histamine effects on sooth muscle and immune cells and does not affect the muscarinic and a adrenoceptors

Answer 8

Cetirizine

Question 9

Other second generation of H2 blockers that are similar to cetirizine

Answer 9

Loratidine
Desloratidine
Fexofenadine

Question 10

H2 antihistamine

Answer 10

Cimetidine

Question 11

A serotonin agonist that reduce the release of calcitonin gene-related peptide and perivascular edema in cerebral circulation

Answer 11

Sumatriptan

Question 12

Is sumatriptan a partial agonist or full agonist?

Answer 12

Partial agonist

Question 13

Drug used in 5-HT1B/1Dreceptors

Answer 13

Sumatriptan

Question 14

Agonist at 5-HT2c receptors

Answer 14

Lorcaserin

Question 15

This effect on the drug appears to reduce appetite

Answer 15

Lorcaserin

Question 16

This drug is used for obesity

Answer 16

Lorcaserin

Question 17

SE of lorcaserin

Answer 17

Headache, constipation, dizziness

Question 18

A partial agonist drug that binds to 5-HT4 receptors

Answer 18

Tegaserod

Question 19

5-HT2 serotonin blocker that prevents vasoconstriction and bronchospasm of carcinoid syndrome

Answer 19

Ketanserin

Question 20

Clinical application of ketanserin

Answer 20

Hypertension
Carcinoid tumor

SE: hypotension

Question 21

5-HT3 antagonist that blocks chemoreceptor trigger zone and ENS

Answer 21

Ondansetron

Question 22

SE of this drug: QRS and QT prolongation

Answer 22

Dolasetron

Question 23

SE of this antagonist drug that blocks 5-HT3: constipation

Answer 23

Alosetron

Question 24

An ergot alkaloid that is A mixed partial agonist at 5-HT2 and a adrenoceptors that contracts SM bt blocks a-agonist vasoconstriction

Answer 24

Ergotamine

Question 25

An ergot alkaloid that is a prototype of vasoseelctive drug

Answer 25

Ergotamine

Question 26

An ergot alkaloid that is a prototype for uteroselective drugs

Answer 26

Ergonovine

Question 27

This drug has the same effects as ergotamine but it is only selective for uterin smooth muscle contraction

Answer 27

Ergonovine

Question 28

Clinical app: postpartum bleeding

Answer 28

Ergonovine

Question 29

A prototype of CNS selective drug

Answer 29

Lysergic acid diethylamide

Question 30

MOA: mixed partial agonist at CNS 5-HT2 and dopamine agonist . 5-HT2 antagonist in periphery

Answer 30

Lysergic acid diethylamide

Question 31

Effects of this drug: psychotomimetic

Answer 31

Lysergic acid diethylamide

Question 32

Toxicity of LSD

Answer 32

Prolonged psychotic state, flashbacks

Question 33

MOA of H1

Answer 33

SM, endothelium and brain

Question 34

MOA of H2

Answer 34

Gastric mucosa,cardiac muscle, mast cell and brain

Question 35

MOA of H3

Answer 35

Presynaptic autoeceptors and heteroceptors, myenteric plexus, brain

Question 36

MOA of H4

Answer 36

Eosinophils, neutrophils and CDT4 cells