LObj Chp 21 Flashcards
Identify components that comprise the lymphatic system
Lymph, lymphatic vessels, lymphatic tissues, Red bone marrow & Thymus
Lymph
(The recovered Interstital fluid that passed through lymphatic vessel) Clear colorless fluid with little protein that originate as ECF drawn into lymphatic capillaries.
Lymphatic vessels
Makeup of unified lymphatic capillaries(one ended closed) that return lost plasma proteins to blood stream
Lymphatic tissues
Makeup of lymphocytes and macrophages in the ct of mucous membranes(MALT Mucosa-Associated-lymphatic-Tissue and various organs.
Lymphatic Organs (Primary) (Red Bone Marrow, Thymus)
Site where stem cells T, and B divide and become IMMUNOCOMPETENT, and are able to recognize and respond to foreign antigens.
Lymphatic Organs(Secondary) Lymph nodes, tonsils, spleen, lymphatic nodules
Sites that deliver/execute/carry out immune responses
Major Functions of Lymphatic System
*Maintaining Homeostasis by
-draining excess interstital fluid
- lipid absorption and transport of dietary lipids
- providing defense against disease through immune responses
Anatomy of (Lymph Capillaries vs Blood Capillaries)
Lymph Capillaries: Blind ended, with overlapping endothelial cells creating mini-valves, often lacking a complete basement membrane, anchored to surrounding tissue by filaments.
Blood Capillaries: Continuous loop structure, with tight junctions between endothelial cells, usually with a complete basement membrane.
Lacteals
[Absorbs dietary fats]Specialized lymph capillaries present within small intestine villi that absorbs fats.
Formation and composition of lymph fluid
Leaking of interstitial fluid from capillaries into tissues which is then collected by lymphatic capillaries of lymphatic tissue.
Composition: water, proteins, electrolytes, WBCs, lymphocytes/ cellular debris from tissue.
Excessive fluid from blood plasma
Interstitial Fluid
Natural Killer Cell
Lymphatic cell that functions to non-specifically target bacteria, transplanted tissue cells, and virally infected or cancerous host cells.
Plasma cells
Originated as a B cell, eventually B cells differentiate into an antibody that produces plasma cells
Macrophages
Cells derived from monocytes that function as phagocytes and antigen-presenting cells are called macrophages
Lymph Circulation
1.Lymphatic capillaries absorb Interstitial fluid which turns to lymph
2. Lymph is drained by lymphatic capillaries into [collecting/lymphatic] vessels ………..
Thymus Gland
Provides suitable environment for T cell development, and selection, ensuring functional/self tolerant cells are released into circulation. (Adpative Immunity)
#Location: in the Anterior Mediastinum, above heart/ between lungs.
-most active during childhood and atrophies with age
Capsule(Thymus):
CT layer surrounding the thymus, providing protection and structural support.
Trabeculae(thymus)
Extensions of the capsule that divide the gland into lobules, creating a framework for the tissue.
Cortex(Thymus)
Outer region of each lobule, densely packed with [(immature T cells)-thymocytes] and epithelial cells
Medulla(Thymus)
inner region of each lobule, containing mature T cells and fewer epithelial cells, often with Hassall’s corpuscles
Lymph Nodes
(Filter of lymph fluid) by trapping pathogens and foreign particles.
# Serve as a site for lymphocyte activation and proliferation(plays a crucial role in immunology response)
Spleen
Blood filterer, removes old/damaged rbcs and pathogens.
#serves as a reservoir for blood and is a site for the activation of immune responses.
Location: Located in the upper left abdomen, behind stomach/ beneath diaphragm.
Capsule(spleen)
Dense CT layer that protects spleen
Trabeculae(Spleen)
Divides spleen into compartments via extensions from capsule
