Liver (Washington) Flashcards
Define steatosis
Fatty infiltration of the liver (TGs and other fats inside hepatocytes)
Define steatohepatitis
When inflammation is a/w fatty infiltration of the liver
Define cirrhosis
- Chronic degenerative disease
- Hepatocytes are damaged and replaced by scar tissue
- Results in decreased function of the liver
What is AST? What does it test for?
- Aspartate Aminotransferase
- Enzyme normally found in RBCs, liver, heart, muscle, pancreas, kidneys
- Tests for liver damage (along with ALT)
- Formerly called SGOT
What are normal AST levels (generally)?
Low
How is the amount of AST in the blood related to tissue damage?
Directly - more AST in blood means more tissue damage
What does the ratio of AST to ALT tell us?
Whether liver or another organ has been damaged
Which liver lab test component is mainly found in liver tissue?
ALT
AST is less specific
Which is more specific to the liver - ALT or AST?
ALT
What is ALT? What does it test for?
- Alanine Aminotransferase
- Enzyme found mainly in liver
- Tests for liver damage/disease
- Formerly called SGPT
What are normal values of ALT (generally)?
Low
What is ALP? What does it test for?
- Alkaline Phosphatase
- Enzyme made mostly in liver and bone (some in intestines, kidneys, placenta)
- Non specific
The liver makes more ____ (ALT, AST, ALP) than other organs or bones
ALP
Abnormally elevated levels of ALP could be from:
- Rapid bone growth (puberty)
- HyperPTH
- Vit D deficiency
- Liver damage
What is GGT?
- Gamma glutamyl transpeptidase
- Enzyme in blood that functions as a transport molecule to help liver metabolize drugs/toxins
- Found in many places but NOT bone
- Can help you determine if high ALP is prob due to bone disease
What does a high ALP with a high GGT indicate?
Liver or bile ducts damage
high GGT rules out bone as a cause!
What does a high ALP with a normal GGT indicate?
Bone disease
Define total bilirubin
Amount of bilirubin in a blood sample
How does bilirubin circulate in the blood?
In 2 forms:
- Direct (conjugated)
- Indirect (unconjugated)
Features of indirect bilirubin
- Unconjugated
- Insoluble
- Conjugated in the liver
- Not measured directly form the blood (need total and direct values)
Which type of bilirubin cannot be measured straight from the blood?
Indirect
need total and direct to calculate
Elevated levels of indirect bilirubin indicates:
- Hemolysis
- Failure of liver uptake
Features of direct bilirubin
- Conjugated
- Soluble
- Measured directly in blood
Elevated levels of direct bilirubin indicates:
Impaired secretion of liver
Define albumin, its functions, and what it evaluates
- Protein made by the liver
- Helps move bilirubin, Ca, hormones and meds through blood
- Keeps fluid in blood from leaking out into tissues
- Used to assess liver and kidney disease
Decreased levels of albumin occurs when?
- When body does not get or absorb enough nutrients
- Crohn’s, after wt loss surgery, low protein diets, Celiac
Increased levels of albumin occurs when?
- Dehydration
- High protein diet
Define alcoholic liver disease
-Acute or chronic inflammation
-Parenchymal necrosis of liver
induced by alcohol
What is the MC precursor of cirrhosis in the US?
Alcoholic liver disease
Is alcoholic liver disease reversible or irreversible?
Reversible in early stages
3 major stages of ALD
- Fatty liver
- Alcoholic hepatitis
- Cirrhosis
Features of fatty liver stage of ALD
- Present in 90+% of binge and chronic alcoholics
- Asymptomatic
- Reversible w/cessation of alcohol
Features of alcoholic hepatitis stage of ALD
- 10-20% of alcoholics
- Asymp - symptomatic
- Reversible w/cessation
- Precursor to cirrhosis
What stage of ALD is the precursor to cirrhosis?
Alcoholic hepatitis
What is the first histologic response to any hepatotoxic stimuli (e.g. ETOH)?
Fat accumulation
Where does fat accumulation in the liver occur?
At the location of alcohol dehydrogenase (leading to a deficiency of this enzyme)
What is the hallmark of alcoholic hepatitis?
Hepatocyte injury (degeneration, necrosis, PMN infiltration, fibrosis)
What is the most important risk factor of ALD?
Quantity AND duration of alcohol intake
Who is more susceptible to ALD?
-Females (lower levels of alcohol dehydrogenase to begin with) -Concurrent HCV -Genetics -Fatty liver from obesity
How does ALD occur in pts w/concurrent HCV?
- Develop at a younger age
- Worse survival
What is the amount of alcohol per day threshold for males vs. females in developing ALD?
- Males: 80+ g/d
- Females: 30-40+ g/d
- 1 drink is approx. 12 g
If symptoms are present in early ALD (fatty liver), what would it be?
- Hepatomegaly
- RUQ tenderness (occasionally)
- Nausea
- Jaundice (very rare)
How does advanced (alcoholic hepatitis) ALD present?
- SOME are asymp
- Fever
- Spider nevi
- Jaundice
- Abdominal tenderness
- Encephalopathy
- Portal HTN (ascites, esophageal varices)
What lab abnormalities may be found in early (fatty liver) ALD?
- Modest increase in GGT, AST, ALT
- High TGs
- High cholesterol
- High bilirubin (occasionally)
What lab abnormalities may be found in advanced (alcoholic hepatitis) ALD?
- Severe increase in GGT, AST, ALT, AST:ALT
- High bilirubin (common)
- High ALP
- Low albumin
- Coagulopathy (increased PT)
What imaging is used to evaluate alcoholic liver disease? What does it detect?
Ultrasound:
- Fatty infiltration
- Size of liver
- Biliary obstruction
- Ascites
- CANNOT detect fibrosis or inflammation
Liver ultrasound cannot detect:
Fibrosis and inflammation
What is needed for definitive diagnosis of ALD?
Liver biopsy
U/S cannot detect fibrosis and inflammation
Describe liver biopsy’s role in ALD:
- Needed for definitive diagnosis
- Guides therapy
What does early ALD show on liver biopsy?
Macrovesicular fat
What does advanced ALD show on liver biopsy?
PMN infiltration w/hepatic necrosis, Mallory bodies, and fibrosis
*Findings are non-specific and identical to those of NASH (non-alcoholic steatohepatitis)
General treatment of ALD
- Abstinence from alcohol
- Proper nutrition (including potentially folic acid, thiamine, zinc supplements)
- Psych counseling
Pharmacologic treatment of ALD
- Methylprednisolone with taper MAY reduce short term mortality in alcoholic hepatitis
- Pentoxifylline (TNF-inhibitor) reduces 1 month mortality rates in alcoholic hepatitis
- NO benefit to use both
Surgical treatment of ALD
Liver transplant for end stage cirrhosis