Liver Flashcards
What are the anti-ox that can be used for liver protection?
n-acetylcysteine and silymarin
Common causes in dog vs cat of extrahepatic BD obstruction
breeds associated with chronic hepatitis
doby and spaniels
Breeds and related genetic defects for copper associated chronic hepatitis
What is the biochem makeup of chronic hepatitis
How can chronic hepatitis differ from reactive hepatopathy?
RH- no necresis, inflammation
normal copper tissue level?
stain for copper?
distribution?
<400 ug/g
rhodanine stain
centrilobular
Tx for chronic hepatitis
Chelators for copper chronic hep?
D-penicillamine
trientine
C.S. cirrhosis
How does the body deal with hypertension from cirrhosis?
secondary shunts
activate RAAS system (absorb more Na/H2O from kidneys)
Tx for cirrhosis
spironolactone
anti-fibrotics
(not furosemide- hypoK & metabolic alkalosis-worsen hepatic encephalopathy)
Anti-fibrotic
pred or colchicine
Tx for hepatic encephalopathy
lactulose (increase motility GI and change pH to make absorption ammonia harder)
abx- neomycin & amoxi
restirct protein diet
pre-disposed breeds for congenital PSS
urate stones are often associated with what condition?
Which breeds is it normal?
PSS
dalmation and bulldog
Two classic signs of PSS in cats
ptyalism and copper irises
stunted growth
Common biochem findings for congenital PSS
ammonium biurate crystals
microcytic anemia
Tx for congenital PSS
Key biochem findings with vacuolar hepatopathy
high ALP but normal BR
Tx for vacuolar hepatopathy
the most common cause of incrase liver enzymes is
extra-hepatic dz
Key findings with reactive hepatopathies?
no necrosis
neutrophilic vs. mononuclear inflammation
hepatitis in the dog is to ….. in the cat
cholangitis
Namt the two types of cholangitis
breed for lymphocytic cholangitis in cats
persians
type of anemia associated with cholangitis
non-regen normochromic, normocytic
Tx for NT cholangitis
Tx for lymphocytic cholangitis
Risk factor for hepatic lipidosis
rapid weight loss and obesity
biochem profile for hepatic lipidosis
increase ALP (more than ALT)
normal/midly increase GGT
Tx for feline hepatic lipidosis
