Liver Flashcards
Liver
The largest organ in the body, next to the
skin
Weighs approx 1500 grams in the adult
Intraperitoneal organ
Liver position
-Occupies almost all of the right hypochondrium, the greater part of the epigastrium, and the left hypochondrium
-Inferior to the diaphragm
-The posterior border is in contact with the
right kidney and inferior vena cava
-The aorta lies posterior to the left lobe of the liver
Liver is covered by
Glisson’s Capsule
The subphrenic space
between the liver and the diaphragm
common site for abscess formation.
The right subhepatic space
includes Morison’s pouch
common space for periotoneal fluid or blood to collect
Lesser sac
enclosed portion of the peritoneal space posterior to the liver and stomach
another site for abscess formation
Only a small area is left uncovered
the bare area
In early embryonic life
responsible for hemopoiesis
Lobules contain
hepatocytes, biliary epitheleal cells, and Kupfer cells
Each lobule surrounded by
portal triads, small branches of PV,BD, and HA
Separates anterior and posterior segment of the right lobe
Right hepatic vein
Right intersegmental ligament
Lobes of Liver
Right lobe, Left lobe, Caudate lobe
Separates the lateral and medial segment of the left lobe of the liver
Left hepatic vein Left intersegmental fissure Ligamentum teres Falciform ligament
Separates the right lobe from the left lobe
Middle hepatic vein
Main lobar fissure
Gallbladder fossa
Right Lobe
Largest of the 3 lobes
Contains 3 fossae: 1. porta hepatis 2.gallbladder 3. IVC
divides the right and left lobes
Main lobar fissure
Riedels lobe
A congenital variant,can sometimes be seen as an anterior projection of the liver sometimes extending down to the iliac crest
Left Lobe
Size varies, Can be found just under xiphoid process
Divides the caudal aspect into medial and lateral segments
Falciform ligament and the fissure for the ligamentum teres
Attaches the liver to the diaphragm & anterior abdominal wall
Falciform ligament
Falciform ligament
contains the ligamentum teres, triangular or rounded hyperechoic structure which is the termination of the falciform ligament
Smallest lobe, Situated inferior to the ligamentum venosum
and superior to the inferior vena cava
Caudate Lobe
Main lobar fissure
boundary between the right and left lobes of the liver
On longitudinal scan- it may be seen as a hyperechoic line extending from the portal vein to the neck of the gallbladder
Main lobar fissure
extends from the umbilicus to the diaphragm,
contains the ligamentum teres
Falciform ligament
appears as a bright, echogenic triangle on transverse scan, separates the medial and lateral segments of the left lobe of the liver
Ligamentum teres
Ligamentum venosum
fibrous remnant of the ductus venosus of the fetal circulation
supplies 70-75 percent of the blood volume to the liver from the digestive system
Portal venous system
hepatopetal
toward the liver
The RPV
the largest and further divides into the anterior and posterior
enters the liver at the portahepatis
Main portal vein (MPV)
divides into the right (RPV) and left portal veins (LPV)
Main portal vein (MPV)
Left portal vein
lies more anterior and cranial than the RPV
Divides into the medial and lateral branch
Left portal vein
Lies within a thick band of connective tissue
coursing through the central portion of the lateral segment of the left lobe
Left portal vein
What do hepatic veins flow into?
Inferior Vena Cava
What veins have hepatofugal flow (below the baseline)?
Hepatic Veins
What veins have hepatopetal flow (above the baseline)?
Portal Veins
Why do portal veins have bright walls?
bright connective tissue called Glisson’s Capsule
What veins drain blood from liver back to IVC?
Hepatic Veins
What 3 components are hepatic veins divided into?
Right (RHV), Middle (MHV), and Left (LHV)
What direction is flow going towards in hepatic veins?
Hepatifugle
How are hepatic veins distinguished from portal veins?
Hepatic veins lack bright walls
Do hepatic veins have high or low velocity? & Is the velocity of flow greater or less than portal veins?
Low; greater due to closer proximity to heart
What percentage of the livers blood supply comes from hepatic arteries?
20%
The common hepatic artery comes off which branch of the aorta?
Celiac trunk
Hepatic enzymes
Increased quantities in the blood is a sensitive indicator of hepatocellular disorder.
As the hepatic arteries course toward the right and towards porta hepatis, what is it called?
Proper hepatic artery
At the porta hepatis, what does the proper hepatic artery divide into?
Right, middle, and left
What does the right hepatic artery course between
Bile Duct and Portal Vein
What are the primary functions of the liver?
Metabolism, Digestion, Storage, Detoxification, and Phagocytosis
What metabolic function converts dietary sugars into glucose and releases glucose into blood?
Carbohydrate Metabolism
Hypoglicemic
not enough sugar in the blood
Hyperglicemic
too much sugar in the blood
What metabolic function converts hepatocytes into lipoproteins?
Fat Metabolism
What metabolic function converts amino acids into albumin and other proteins?
Protein Metabolism
In liver disease, decreased production of proteins can lead to hemorrhage. This deficiency is due to lack of what vitamin?
Vitamin K
What cells engulf and breakdown toxic matter in the liver?
Kupffer cells
List the different liver function tests
AST, ALT, LDH, Alk Phos, Bilirubin, PT, Albumin and globulins
Aspartate aminotransferase (AST)
enzyme produced in high-metabolic tissues
may indicate cirrhosis, fatty liver, hepatitis, and metastatic liver disease
Alanine aminotransferase (ALT)
more specific in evaluating liver disease the AST
may indicate hepatitis, hepatocellular disease, and obstructive jaundice
Lacate Dehydrogenase (LDH)
may indicate hepatitis, cirrhosis, obstructive jaundice
Serum Bilirubin (bilirubin)
pigment released when red blood cells are broken down
Conjugated- biliary tract disease
Unconjugated- hepatocellular disease
Total - cirrhosis and other chronic liver disease
Alkaline Phosphate (alk phos)
produced by liver, bone, intestines, and placenta
indicates cirrhosis, extrahepatic biliary obstruction, gallstones, hepatitis, metastatic liver disease, and pancreatic carcinoma
Prothrombin (PT)
liver enzyme that is part of the blood clotting system
dependent on adequate intake of Vitamin K
Liver Scanning (correct TGC, gain, depth, focus, and frequency)
TGC - adjusted to balance far and near field echoes
Gain - adjusted to show liver as homogeneous
Depth - Rt Lobe should be positioned on lower border
Focus - near posterior border of liver
Frequency - 2.5-5 MHz in adults 5-7 MHz in children
porta hepatis
a deep fissure in the inferior surface of the liver through which all the neurovascular structures (except hepatic veins) and hepatic ducts enter or leave the liver