Liver Flashcards
The caudate and quadrate lobes are found within the posterior surface of the (right/left) lobe
The caudate and quadrate lobes are found within the posterior surface of the right lobe
The caudate and quadrate lobes are separated by the _
The caudate and quadrate lobes are separated by the porta hepatis which contains the vasculature
* The portal triad enters at the porta hepatis
25% of the liver’s blood supply comes from the _
25% of the liver’s blood supply comes from the proper hepatic artery
* Carries oxygenated blood to the liver
75% of the liver’s blood supply comes from the _
75% of the liver’s blood supply comes from the portal vein
* Carries blood from the GIT to the liver to be filtered
Blood leaving the liver drains through the _
Blood leaving the liver drains through the hepatic vein –> IVC
The hepatic lobule is _ shaped
The hepatic lobule is hexagonally shaped
Four regions of the hepatic lobule on histology include _ , _ , _ , _
Four regions of the hepatic lobule on histology include portal triad –> zone 1 –> zone 2 –> zone 3 –> central vein
The portal triad includes _ , _ and _
The portal triad includes portal vein, hepatic artery, bile duct
Portal traid –> zone 1 –> zone 2 –> zone 3 –> ??
Portal traid –> zone 1 –> zone 2 –> zone 3 –> central vein
Viral hepatitis mostly affects zone _
Viral hepatitis mostly affects zone 1
Ischemia is most common in zone _
Ischemia is most common in zone 3
Ingested toxins most affect zone _
Ingested toxins most affect zone 1
Yellow fever mostly affects zone _
Yellow fever mostly affects zone 2
CYP450 is most concentrated in zone _
CYP450 is most concentrated in zone 3
Metabolic toxins and alcoholic hepatitis mostly affect zone _
Metabolic toxins and alcoholic hepatitis mostly affect zone 3
* This is where CYP450 is most concentrated
We have specialized calls called _ located in the space of disse between sinusoids and hepatocytes
We have specialized calls called stellate cells (ito cells) located in the space of disse between sinusoids and hepatocytes
Stellate cells are normally quiescent and function to store _
Stellate cells are normally quiescent and function to store vitamin A
When activated, stellate cells mediate _ and _
When activated, stellate cells mediate liver repair and fibrosis
_ are specialized macrophages found in the sinusoids of the liver
Kupffer cells are specialized macrophages found in the sinusoids of the liver
AST is a liver enzyme that stands for _
AST is a liver enzyme that stands for aspartate aminotransferase
ALT is a liver enzyme that stands for _
ALT is a liver enzyme that stands for alanine aminotransferase
The ratio of _ is classically elevated in alcoholic liver disease
The ratio of AST/ALT is classically elevated in alcoholic liver disease
If AST/ALT is elevated in non-alcoholic liver disease, it is suggestive of _
If AST/ALT is elevated in non-alcoholic liver disease, it is suggestive of advanced cirrhosis/fibrosis
Super high aminotransferases signals _
Super high aminotransferases signals drug-induced liver disease, ischemic, viral, autoimmune hepatitis
Cholestasis, infiltrative disorders, or bone diseases may cause increased _ levels
Cholestasis, infiltrative disorders, or bone diseases may cause increased alkaline phosphatase (ALP) levels
GGT stands for _ ; it can be elevated in liver or biliary disease
GGT stands for gamma-glutamyl transpeptidase ; it can be elevated in liver or biliary disease
Gamma-glutamyl transpeptidase (GGT) is associated with _
Gamma-glutamyl transpeptidase (GGT) is associated with alcohol use
Name some hepatic lab values that may be abnormal in liver disease
- Bilirubin: increased in biliary and liver disease, hemolysis
- Albumin low in advanced liver disease
- Clotting factors low in advanced liver disease
- Thrombopoietin low in advanced liver disease; thrombocytopenia
Two reasons why platelets are low in liver disease (2):
Two reasons why platelets are low in liver disease (2):
1. Thrombopoietin is made by the liver; decreased production of platelets
2. Sequestration by liver and spleen
(3) stages of alcoholic hepatitis
(3) stages of alcoholic hepatitis:
1. Hepatic steatosis
2. Alcoholic hepatitis
3. Alcoholic cirrhosis
Hepatic steatosis can be characterized by (reversible/irreversible) (micro/macro) vesicular fatty changes in the liver
Hepatic steatosis can be characterized by reversible, macrovesicular fatty changes in the liver
Explain how alcohol damages the liver over time, causing hepatic steatosis
Alcohol –> alcohol dehydrogenase –> acetaldehyde –> NADH production –> decreased free fatty oxidation –> lipid accumulation
Acetaldehyde (produced by alcohol dehydrogenase) generates NADH which (increases/decreases) free fatty oxidation
Acetaldehyde (produced by alcohol dehydrogenase) generates NADH which decreases free fatty oxidation –> lipid accumulation –> fatty liver
Alcoholic hepatitis can be diagnosed via _ findings
Alcoholic hepatitis can be diagnosed via:
* AST/ALT > 2
* Low albumin
* Leukocytosis
* High GGT
* High ALP
Alcoholic hepatitis has what effect on bilirubin?
Alcoholic hepatitis causes a mixed hyperbilirubinemia
* Increased unconjugated and conjugated bilirubin
Alcoholic hepatitis may present with _ on physical exam
Alcoholic hepatitis may present with:
* Painful hepatomegaly
* Jaundice
* Ascites
* Anorexia
Alcohol ingestion that leads to alcoholic hepatitis may cause the release of inflammatory markers like _
Alcohol ingestion that leads to alcoholic hepatitis may cause the release of inflammatory markers like cytokine IL-8 –> recruits neutrophils
Alcoholic hepatitis is associated with intracytoplasmic keratin deposits called _
Alcoholic hepatitis is associated with intracytoplasmic keratin deposits called Mallory bodies
Fibrosis and steatosis associated with alcoholic hepatitis begins in zone _
Fibrosis and steatosis associated with alcoholic hepatitis begins in zone 3 (centrilobular)
_ is the irreversible progression of alcoholic hepatitis
Alcoholic cirrhosis is the irreversible progression of alcoholic hepatitis
Alcoholic cirrhosis can be characterized by _ on histology
Alcoholic cirrhosis can be characterized by sclerosis around central veins and regenerative nodules surrounded by fibrosison histology
The consequence of fibrosis in alcoholic cirrhosis is the formation of _ and _
The consequence of fibrosis in alcoholic cirrhosis is the formation of portal hypertension and shunts
* Varices
Cirrhosis can also lead to (increase/decrease) in ammonia metabolism
Cirrhosis can also lead to decreased ammonia metabolism
* Ammonia build up –> encephalopathy
Alcoholic hepatitis is associated with _ anemia
Alcoholic hepatitis is associated with macrocytic anemia
* Deficiency of B1, B9, B12 associated with excessive alcohol use
Non-alcoholic hepatic steatosis is most commonly caused by _
Non-alcoholic hepatic steatosis is most commonly caused by obesity, metabolic syndromes
* Fat accumulates in the liver –> can progress to cirrhosis
Non-alcoholic hepatic steatosis is associated with an increased _ ratio
Non-alcoholic hepatic steatosis is associated with an increased ALT/AST
* Reverse of alcoholic hepatitis
Non-alcoholic hepatic steatosis can be characterized by _ on histology
Non-alcoholic hepatic steatosis can be characterized by fatty infiltration of hepatocytes –> cellular ballooning –> necrosis
Non-alcoholic hepatic steatosis is associated with:
Non-alcoholic hepatic steatosis is associated with:
* Native americans
* Obesity
* Diabetes
We can manage non-alcoholic hepatic steatosis with drugs like _ or _
We can manage non-alcoholic hepatic steatosis with drugs like metformin or TZDs
Alcoholic cirrhosis
* Blue fibrosis
* Nodular liver
Alcoholic hepatitis
* Mallory bodies
Etiology for cirrhosis includes:
Etiology for cirrhosis includes:
* Alcohol use disorder
* Non-alcohol steatohepatitis
* Viral hepatitis
* Autoimmune
* Genetic disorders
* Medications
Cirrhosis results from chronic inflammation that activate _ cells
Cirrhosis results from chronic inflammation that activate stellate (Ito) cells in the hepatic sinusoids
The central mediator of fibrogenesis in liver cirrhosis is _
The central mediator of fibrogenesis in liver cirrhosis is TGF-beta –> fibrosis, nodular scarring
How does cirrhosis lead to portal hypertension?
Fibrosis disrupts normal hepatic architecture –> vasculature is disrupted –> portal hypertension –> varices
Cirrhosis can cause _ which manifests as ascites and edema
Cirrhosis can cause hypoalbuminemia which manifests as ascites and edema
How does cirrhosis cause splenomegaly?
Cirrhosis –> portal hypertension –> splenomegaly –> splenic sequestration of plateletes –> thrombocytopenia –> increased bleeding time
Cirrhosis is associated with decreased clotting factors and decreased TPO production which manifests as _
Cirrhosis is associated with decreased clotting factors and decreased TPO production which manifests as coagulopathies, increased PT, increased INR
Clotting factor _ is a good measure of liver function since it has a short half life
Factor VII is a good measure of liver function since it has a short half life
Cirrhosis may present with hypokalemia due to _
Cirrhosis may present with hypokalemia due to impaired aldosterone metabolism
Cirrhosis may present with hyponatremia (despite high aldosterone) due to _
Cirrhosis may present with hyponatremia (despite high aldosterone) due to decreased intravascular volume –> triggering ADH secretion
Cirrhosis can impair normal biochemical processes that occur in the liver such as _
Cirrhosis can impair normal biochemical processes that occur in the liver such as gluconeogenesis, glycogenolysis –> hypoglycemia
Spider angiomas and palmar erythema are dermatologic manifestations of _ that is caused by cirrhosis
Spider angiomas and palmar erythema are dermatologic manifestations of decreased estrogen metabolism that is caused by cirrhosis
Gynecomastia can be caused by cirrhosis; how?
Low androstenedione, low estrogen metabolism –> high serum estrogen –> increases sex hormone binding globulin –> decrease in free testosterone –> gynecomastia, ED, amenorrhea
Stellate cells largely respond to the release of _ during chronic inflammation
Stellate cells largely respond to the release of TGF-beta during chronic inflammation
Cirrhosis may present with general symptoms like:
Cirrhosis may present with general symptoms like:
* Fatigue
* Nausea
* Vomiting
* Abdominal pain
* Anorexia
* Jaundice
Signs of portal hypertension and hypoalbuminemia in cirrhosis include:
Signs of portal hypertension and hypoalbuminemia in cirrhosis include:
* Ascites
* Edema
* Varices
Which type of varices are most prone to rupture? (esophageal/ umbilical/ gastric/ anorectal)
Which type of varices are most prone to rupture? Esophageal
_ is a halitosis unique to cirrhosis
Fetor hepaticus is a halitosis unique to cirrhosis
An individual with cirrhosis may have stinky breath that smells like _
An individual with cirrhosis may have stinky breath that smells like sulfur
* Due to the build up of sulfur containing compounds
Cirrhosis and ascites can progress to ?
Cirrhosis and ascites can progress to fever, abdominal pain, ileus, encephalopathy
_ occurs when the free fluid associated with cirrhosis (ascites) becomes infected
Spontaneous bacterial peritonitis occurs when the free fluid associated with cirrhosis (ascites) becomes infected
The most common bacteria responsible for spontaneous bacterial peritonitis are _ , _ , _
The most common bacteria responsible for spontaneous bacterial peritonitis are E.coli , Klebsiella , Streptococcus
Spontaneous bacterial peritonitis is diagnosed via paracentesis of ascitic fluid which reveals an absolute neutrophil count > _
Spontaneous bacterial peritonitis is diagnosed via paracentesis of ascitic fluid which reveals an absolute neutrophil count > 250
We treat spontaneous bacterial peritonitis with _
We treat spontaneous bacterial peritonitis with third gen cephalosporin (ceftriaxone, cefotaxime)
Hepatic encephalopathy is caused by _
Hepatic encephalopathy is caused by increased ammonia build up; decreased ammonia metabolism
* Result of portal hypertension, portosystemic shunts
A patient with asterixis (flapping tremor), confusion, disorientation, drowsiness and history of cirrhosis should be concerning for _
A patient with asterixis (flapping tremor), confusion, disorientation, drowsiness and history of cirrhosis should be concerning for hepatic encephalopathy
Hepatic encephalopathy can be treated with a drug that increases NH4+ generation like _
Hepatic encephalopathy can be treated with a drug that increases NH4+ generation like lactulose
_ and _ are two drugs that may be indicated in encephalopathy to decrease the NH3 produced by gut bacteria
Rifaximin and neomycin are two drugs that may be indicated in encephalopathy to decrease the NH3 produced by gut bacteria
A patient with alcohol use disorder and confusion, ophthalmoplegia (paralysis of extraocular muscles), ataxia may have _
A patient with alcohol use disorder and confusion, ophthalmoplegia (paralysis of extraocular muscles), ataxia may have Wernicke’s encephalopathy (thiamine deficiency)
Wernicke’s encephalopathy may progress to Wernicke-Korsakoff syndrome which presents with _
Wernicke’s encephalopathy may progress to Wernicke-Korsakoff syndrome which presents with confabulation, memory loss, personality change
Explain the pathogenesis of hepatorenal syndrome
Liver failure –> increase in NO –> splanchnic vasodilation –> decrease in systemic BP –> renal hypoperfusion –> increased RAAS –> High RAAS with impaired aldosterone metabolism –> Hepatorenal syndrome
* Can see progressive loss of RBF, renal failure
(3) Mechanisms in which EtOH damages the liver
(3) Mechanisms in which EtOH damages the liver
1. Hepatic fat; normally NAD helps to oxidize fat but it is also used to oxidize alcohol; all of the NAD gets consumed trying to metabolize the alcohol
2. Direct hepatotoxicity: acetaldehyde
3. Hepatic inflammation: IL-7, IL-8, TNFa
Normally the liver will metabolize fat and cholesterol and transport them out of the liver into the circulation as _
Normally the liver will metabolize fat and cholesterol and transport them out of the liver into the circulation as VLDL
* So a healthy liver only has a small amoutn of fat within the liver
Abnormal or excessive fat accumulation in the liver is called _
Abnormal or excessive fat accumulation in the liver is called steatosis
Gross pathology and PE of a steatotic liver may reveal _
Gross pathology and PE of a steatotic liver may reveal hepatomegaly
* However, it is clinically asymptomatic
The two major causes of steatosis are _ and _
The two major causes of steatosis are alcohol associated liver disease and metabolic dysfunction- associated steatotic liver disease (MASLD)
Which processes are reversible? Steatosis –> steatohepatitis –> fibrosis
Steatosis: reversible
Steatohepatitis: maybe reversible
Fibrosis: irreversible
Alcohol related steatohepatitis showing mallory bodies and neutrophilic inflammation
The most important management for alcohol-related hepatitis is _
The most important management for alcohol-related hepatitis is alcohol cessation
When liver disease progresses to cirrhosis we see (enlargement/shrinking) of the liver
When liver disease progresses to cirrhosis we see shrinking of the liver from the fibrosis
* Remaining healthy hepatocytes try to proliferate via “regenerative nodules”
Cirrhosis: shows bridging fibrosis + regenerative nodule formation
Although alcoholic cirrhosis will have mixed bilirubinemia, more of it will be (conjugated/unconjugated)
Although alcoholic cirrhosis will have mixed bilirubinemia, more of it will be unconjugated
Name some of the physical exam findings associated with cirrhosis
Portal hypertension can lead to _
Portal hypertension can lead to…
* Esophageal varices
* Rectal varices
* Caput medusae
* Splenomegaly
Variceal bleeding can be life-threatening (50% mortality); we treat esophageal varices with _
Variceal bleeding can be life-threatening (50% mortality); we treat esophageal varices with urgent EGD with banding
Hepatic encephalopathy is caused by an increase in ammonia and _
Hepatic encephalopathy is caused by an increase in ammonia and glutamine
* Ammonia crosses BBB and causes glutamate –> glutamine
We screen patients with cirrhosis for _ cancer
We screen patients with cirrhosis for hepatocellular cancer (HCC)
Viral hepatitis involves _ mediated hepatocyte apoptosis
Viral hepatitis involves CD8+ T-cell mediated hepatocyte apoptosis
* Leads to inflammation of the lobules and portal tracts
The first zone affected by viral hepatitis is the _ zone
The first zone affected by viral hepatitis is the periportal, zone 1
Viral hepatitis causes elevation in liver enzymes: _ > _
Viral hepatitis causes elevation in liver enzymes: ALT > AST
The prodrome of viral hepatitis manifests as:
The prodrome of viral hepatitis manifests as:
* Fever
* Anorexia
* Nausea
* Vomiting
Later manifestations of viral hepatitis include:
Later manifestations of viral hepatitis include:
* Jaundice
* Pruritis
* Pale stool
* Dark urine
Viral hepatitis is associated with an increase in _ bilirubin
Viral hepatitis is associated with an increase in conjugated and unconjugated bilirubin
Causes of viral hepatitis:
Causes of viral hepatitis:
* Hepatitis A-E
* EBV, CMV, yellow fever
Hepatitis A is a (ss/ds) (DNA/RNA) virus in the _ family
Hepatitis A is a ss RNA picornavirus
Hepatitis B is a (ss/ds) (DNA/RNA) virus in the _ family
Hepatitis B is a ds DNA hepadnavirus
Hepatitis C is a (ss/ds) (DNA/RNA) virus in the _ family
Hepatitis C is a ss RNA flavivirus
Hepatitis D is a (ss/ds) (DNA/RNA) virus in the _ family
Hepatitis D is a ss RNA deltavirus
Hepatitis E is a (ss/ds) (DNA/RNA) virus in the _ family
Hepatitis E is a ss RNA hepevirus
All hepatitis viruses (A-E) are ss-RNA viruses except for _
All hepatitis viruses (A-E) are ss-RNA viruses except for Hepatitis B
* Hep B is a ds DNA hepadnavirus
Hepatitis _ and _ viruses have no envelope so therefore can be consumed
Hepatitis A and E viruses have no envelope so therefore can be consumed
Hepatitis A is transmitted via fecal-oral exposure from _
Hepatitis A is transmitted via fecal-oral exposure from contaminated shellfish
* Causes a self-limited infection with a short incubation period
Hepatitis A is characterized by _ on histology
Hepatitis A is characterized by councilman bodies on histology
* Eosinophilic globule of apoptotic hepatocytes
Hepatitis B is transmitted via _
Hepatitis B is transmitted via blood, unprotected sex, during birth
Hepatitis _ and _ commonly lead to chronic hepatitis and increase the risk for hepatocellular carcinoma
Hepatitis B and C commonly lead to chronic hepatitis and increase the risk for hepatocellular carcinoma
Hepatitis B can cause HCC via cirrhosis or via a direct pathway; explain
Hep-B DNA integrates into hepatocytes –> suppression of p53 –> HCC
Hepatitis B has a _ appearance on liver biopsy
Hepatitis B has a “ground glass” eosinophilic appearance on liver biopsy
Hep B can be treated with _ , _ , _
Hep B can be treated with Interferon alpha , lamivudine , tenofovir
Hepatitis C is transmitted via _
Hepatitis C is transmitted via blood- transfusions, IV drug use
Hepatitis C is characterized by _ and _ on liver biopsy
Hepatitis C is characterized by macrovesicular steatosis and lymphoid aggregates on liver biopsy
Treatments for Hep C include:
Treatments for Hep C include:
* Ribavirin
* Simeprevir
* Sofosbuvir
* Interferon alpha
Hepatitis D requires the presence of _ to replicate
Hepatitis D requires the presence of hepatitis B to replicate
A co-infection in the context of Hepatitis D is when _
A co-infection in the context of Hepatitis D is when the patient simultaneously acquires hep B and D
Hepatitis E is commonly transmitted via _
Hepatitis E is commonly transmitted via contaminated water
A super-infection in the context of hepatitis D is when _
A super-infection in the context of hepatitis D is when patient with chronic hep B acquires hepatitis D –> rapid progression of cirrhosis
* This is worse than a co-infection
_ hepatitis can cause acute icteric hepatitis but is rarely chronic
Hepatitis E can cause acute icteric hepatitis but is rarely chronic
_ is a parasitic liver disease that is caused by the ingestion of eggs in dog stool that causes RUQ pain, N/V, hepatomegaly; can cause anaphylaxis, fever, eosiniphilia if the cysts rupture
Echinococcus granulosus is a parasitic liver disease that is caused by the ingestion of eggs in dog stool that causes RUQ pain, N/V, hepatomegaly; can cause anaphylaxis, fever, eosiniphilia if the cysts rupture
Entamoeba histolytica is a parasitic liver disease that is transmitted via _
Entamoeba histolytica is a parasitic liver disease that is transmitted via cysts in contaminated water
* Trophs invade gut wall and migrate to the liver
Parasite that causes hydatid liver cysts with eggshell calcifications and internal septations:
Parasite that causes hydatid liver cysts with eggshell calcifications and internal septations: echinococcus granulosus
Bloody diarrhea, flask shaped ulcers in colon, hepatic abscesses with anchovy past exudate
Bloody diarrhea, flask shaped ulcers in colon, hepatic abscesses with anchovy past exudate: entamoeba histolytica
The liver fluke _ is called the chinese liver fluke; it is transmitted via _
The liver fluke Clonorchis sinensis is called the chinese liver fluke; it is transmitted via ingestion of undercooked fish
* Causes cholangitis, biliary fivrosis, pigmented gallstones, risk of cholangiocarcinoma
The most common primary liver cancer is _
The most common primary liver cancer is hepatocellular carcinoma
* Spreads hematogenously
The risk for hepatocellular carcinoma increases from _ or _
The risk for hepatocellular carcinoma increases from cirrhosis or genetic disorders (hemochromatosis, wilsons, A1AT)
Hepatocellular carcinoma presentation:
Hepatocellular carcinoma presentation:
* Jaundice
* Hepatomegaly
* Ascites
* Anorexia
* Polycythemia
* Hypercholesterolemia
* Hypercalcemia
* Hypoglycemia
HCC can cause thrombosis or compression of the hepatic veins which leads to centrilobular congestion and necrosis called _ syndrome
HCC can cause thrombosis or compression of the hepatic veins which leads to centrilobular congestion and necrosis called Budd Chiari syndrome
Budd-Chiari syndrome will show _ liver on pathology
Budd-Chiari syndrome will show nutmeg liver on pathology
* Mottled appearance of the liver as a result of hepatic venous congestion
HCC is associated with an increase in _ liver protein
HCC is associated with an increase in alpha fetoprotein
MRI with contrast shows _ with HCC
MRI will show central vein congestion (contrast can’t move through)
Wilson’s disease is a _ disorder that can lead to liver damage/cirrhosis
Wilson’s disease is a copper transport disorder that can lead to liver damage/cirrhosis
Wilson’s disease is a (AD/AR) mutation in _
Wilson’s disease is an autosomal recessive mutation in ATP7B
In Wilson’s disease, there is a mutation in ATP7B, a gene that codes for the _
In Wilson’s disease, there is a mutation in ATP7B, a gene that codes for the copper transport ATPase
Wilson’s disease involves a decrease in copper transport into the _ and _
Wilson’s disease involves a decrease in copper transport into the bile and apocerulopasmin
Wilson’s disease causes (high/low) serum ceruloplasmin and (high/low) urinary copper
Wilson’s disease causes low ceruloplasmin and high urinary copper
Wilson’s disease can cause copper accumulation in the _ , _ , _
Wilson’s disease can cause copper accumulation in the basal ganglia , cornea , kidney
* Copper can cause free radical damage to the tissues
* Dystonia, tremor, dementia, hemolytic anemia, renal damage
The corneal deposition of copper results in _ finding on slit lamp examination
The corneal deposition of copper results in Kayser-Fleischer rings finding on slit lamp examination
We can treat wilson’s disease with _ and _
We can treat wilson’s disease with penicillamine, zinc and trientine
* Liver failure can require transplant
Hemochromatosis is an (AD/AR) mutation in the _ gene
Hemochromatosis is an autosomal recessive mutation in the HFE gene (chromosome 6)
Hemochromatosis is most commonly caused by a single point mutation in _
Hemochromatosis is most commonly caused by a single point mutation in C282Y
Hemochromatosis is associated with HLA _
Hemochromatosis is associated with HLA-A3
Hemochromatosis is caused by abnormal iron sensing from a defective _ receptor or _ gene
Hemochromatosis is caused by abnormal iron sensing from a defective transferrin receptor or hepcidin gene
* Leads to increased intestinal iron absorption
Secondary hemochromatosis can be acquired from _
Secondary hemochromatosis can be acquired from repeat blood transfusions
What happens to the following in hemochromatosis:
Ferritin
Iron
TIBC
Transferrin saturation
What happens to the following in hemochromatosis:
High Ferritin
High Iron
Low TIBC
High Transferrin saturation
Iron deposits in _ tissues in hemochromatosis, causing free radical damage
Iron deposits in liver, skin, heart, pancreas, joints in hemochromatosis, causing free radical damage
The “classic triad” of hemochromatosis is:
The “classic triad” of hemochromatosis is:
1. Diabetes
2. Cirrhosis
3. Bronze skin
Hemochromatosis often presents after age _ in men and _ in women
Hemochromatosis often presents after age 40 in men and 50-60 in women
Other manifestations of hemochromatosis include:
Other manifestations of hemochromatosis include:
* Cardiomyopathy
* Arthropathy
* Gonadal dysfunction
* Malabsorption and steatorrhea (pancreatic deposition)
* Increased risk for HCC
Steatosis: deposition of fat within the hepatocyte cytoplasm
Steatohepatitis: steatosis + inflammation and hepatocellular injury
Fibrosis and cirrhosis
The most common cause of hemochromatosis is a _ point mutation in the HFE gene which causes defective _
The most common cause of hemochromatosis is a C282Y point mutation in the HFE gene which causes defective hepcidin
Treatment for hemochromatosis includes _
Treatment for hemochromatosis includes therapeutic phlebotomy to lower iron stores
* Can use chelating agents
Hemochromatosis: periportal hepatocytes with yellow-brown pigment
Hemochromatosis
ATP7B gene encodes _
ATP7B gene encodes transporter in hepatocytes that allows copper excretion in bile and copper incorporation into ceruloplasmin
Wilson’s disease most commonly presents around _ age
Wilson’s disease most commonly presents around age 20s-30s
* Or may present in childhood with liver/neuro sx
* Or not until adulthood as hepatitis, cirrhosis, liver failure
A heme extra-hepatic manifestation of wilson’s disease is _
A heme extra-hepatic manifestation of wilson’s disease is hemolytic anemia
* Copper is damaging to RBC membranes
Wilson’s disease can present with neurological sx such as:
Wilson’s disease can present with neurological sx such as:
* Dystonia
* Parkinson like syndrome
* Memory changes
* Behavior changes
* Dementia
Wilson’s disease can cause _ syndrome (excess excretion of glucose, bicarb, potassium in the urine)
Wilson’s disease can cause fanconi syndrome (excess excretion of glucose, bicarb, potassium in the urine)
* Malabsorption in the proximal tubule
A medication that can be used in Wilson’s disease to prevent copper absorption is _
A medication that can be used in Wilson’s disease to prevent copper absorption is zinc
What are three contributing factors to neonatal jaundice?
- Transiently low UDPGT activity
- Fetal RBCs have shorter lifespan, high turnover
- Newborn gut is sterile so less conversion to urobilinogen
SAAG stands for _
SAAG stands for serum to ascites albumin gradient
We have suspicion for portal hypertension/ cirrhosis when the SAAG is _
We have suspicion for portal hypertension/ cirrhosis when the SAAG > 1.1
We expect greater albumin in the _ than the _ in the case of portal hypertension
We expect greater albumin in the serum than the ascites in the case of portal hypertension
* Hence the high SAAG (serum to albumin ratio)
A high SAAG tells us that the fluid in the ascites is _
A high SAAG tells us that the fluid in the ascites is low in albumin and essentially just hepatic lymph from hepatic sinusoids
Ascites is likely from an extra-hepatic cause if SAAG is _
Ascites is likely from an extra-hepatic cause if SAAG is < 1.1
