lipo 2

Question 1

extracellular disease of fat matabolism?

Answer 1

hyperlipdemias (dyslipidemias, dyslipoproteinnemias)

Question 2

which type?

accumulation of chylomicrons, either due to lipoprotein lipase or apoC2 deficiency

Answer 2

type 1

Question 3

elevated LDL level, mostly due to genetic defects in LDL receptor. “Dominant” so heterozygoutes have high LDL levels, homozygouse -> myocardial infraction in early age

Answer 3

type 2

Question 4

abnormalities of apoE, interferes with uptake of chylomicrons and VLDL remnants. hypothyrodism can produce similar effect

Answer 4

type3

Question 5

most common - VLDL increase due to obesity, alcohol abuse of diabetes.

Answer 5

type 4

Question 6

like type 1, incased VLDL, high chylomicron levels, leads to pancreatitis, eruptive xanthomas

Answer 6

type 5

Question 7

this can also occur with certain liver diseases where biliary excretion is reduced. an abnomral lipoprotein will accumulate. not typically associated with risk of atheroscelrosis

Answer 7

hypercholesterolemia

Question 8

this is analog of triacylglcerols. it is a strong inhibitor of pancreatic lipase. ( lows down lipid digestion, and therefore lipid absorption)

Answer 8

orlistat

Question 9

orlistat is saturated form of ______

Answer 9

lipstatin

Question 10

as saturated fats increases, circulating total ____ level increases

Answer 10

LDL CH

Question 11

3 mechanism of fiber

Answer 11

1. bile acid sequestration
2. reduces insulin rise by slowing CHO absorption
3. produce short chain FA, absorbed by portal vein and reduces CH synthesis